Measurement of Fibrinogen-fibrin-related Antigen in Serum As Aid to Diagnosis of Deep Vein Thrombosis in Outpatients

Overview

Journal Br Med J

Specialty General Medicine

Date 1975 Feb 15

PMID 1115931

Authors

D A Tibbutt

C N Chesterman

M J Allington

E W Williams

T Faulkner

Affiliations

Soon will be listed here.

Abstract

A study of serum levels of fibrinogen-fibrin-related antigen (F.R.-antigen) in outpatients presenting with clinical features suggesting deep vein thrombosis was undertaken. A raised serum level of this antigen (greater than 12 mg/1) is strong evidence in favour of the diagnosis of deep vein thrombosis. It is virtually conclusive evidence if other known causes of a raised level of the antigen are absent. On the other hand, a normal serum level of F.R.-antigen does not exclude even extensive thrombosis, and other objective techniques are required to substantiate the diagnosis.

References

FERREIRA H, MURAT L . An immunological method for demonstrating fibrin degradation products in serum and its use in the diagnosis of fibrinolytic states. Br J Haematol. 1963; 9:299-310. DOI: 10.1111/j.1365-2141.1963.tb06554.x. View

Wood E, Prentice C, McNicol G . Association of fibrinogen-fibrin-related antigen (F.R.-antigen) with postoperative deep-vein thrombosis and systemic complications. Lancet. 1972; 1(7743):166-9. DOI: 10.1016/s0140-6736(72)90568-5. View

Atkins P, Hawkins L . Detection of venous thrombosis in the legs. Lancet. 1965; 2(7424):1217-9. DOI: 10.1016/s0140-6736(65)90638-0. View

Kakkar V, Nicolaides A, Renney J, Friend J, Clarke M . 125-I-labelled fibrinogen test adapted for routine screening for deep-vein thrombosis. Lancet. 1970; 1(7646):540-2. DOI: 10.1016/s0140-6736(70)90769-5. View

Simmons A, Sheppard M, Sibbald R, Tate G, Roberts B . Prognostic value of serum fibrinogen-related antigen levels after myocardial infarction. Br Heart J. 1973; 35(10):997-1001. PMC: 458743. DOI: 10.1136/hrt.35.10.997. View

MERSKEY C, Kleiner G, Johnson A . Quantitative estimation of split products of fibrinogen in human serum, relation to diagnosis and treatment. Blood. 1966; 28(1):1-18. View

Rickman F, Handin R, Howe J, Alpert J, Dexter L, Dalen J . Fibrin split products in acute pulmonary embolism. Ann Intern Med. 1973; 79(5):664-8. DOI: 10.7326/0003-4819-79-5-664. View

Hedner U, Nilsson M . Clinical experience with determination of fibrinogen degradation products. Acta Med Scand. 1971; 189(6):471-7. DOI: 10.1111/j.0954-6820.1971.tb04407.x. View

Allington M . Detection of fibrin(ogen) degradation products by a latex clumping method. Scand J Haematol Suppl. 1971; 13:115-9. DOI: 10.1111/j.1600-0609.1971.tb01996.x. View

10.

Wilson 3rd J, Frenkel E, Pierce A, JOHNSON Jr R, Winga E, Curry G . Spontaneous fibrinolysis in pulmonary embolism. J Clin Invest. 1971; 50(3):474-80. PMC: 291953. DOI: 10.1172/JCI106515. View

11.

Ruckley C, Das P, Leitch A, DONALDSON A, COPLAND W, Redpath A . Serum fibrin-fibrinogen degradation products associated with postoperative pulmonary embolus and venous thrombosis. Br Med J. 1970; 4(5732):395-8. PMC: 1819952. DOI: 10.1136/bmj.4.5732.395. View

12.

Gurewich V, Hume M, Patrick M . The laboratory diagnosis of venous thromboembolic disease by measurement of fibrinogen-fibrin degradation products and fibrin monomer. Chest. 1973; 64(5):585-90. DOI: 10.1378/chest.64.5.585. View