Progress in Cardiovascular Biology: PPAR for the Course

Overview

Journal Nat Med

Specialties General Medicine
Molecular Biology

Date 2001 Jan 3

PMID 11135607

Citations 10

Authors

M A Lazar

Affiliations

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Abstract

Studies on mice lacking the peroxisome proliferator-activated receptor (PPAR) suggest that PPAR ligands reduce lipid accumulation in foamy macrophages, and may target other receptors. These findings warrant an in-depth investigation into the gene regulatory mechanisms of PPAR ligands, which are currently being developed as drugs to treat atherosclerosis and diabetes.

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