» Articles » PMID: 11128558

In Vitro Antimicrobial Activity of Propolis Dry Extract

Overview
Journal J Chemother
Date 2000 Dec 29
PMID 11128558
Citations 26
Authors
Affiliations
Soon will be listed here.
Abstract

In this study the antibacterial and antifungal properties of propolis, a natural product of bees, have been investigated against different pathogens. Minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) were determined according to NCCLS standards on 320 strains including Staphylococcus aureus, Group A beta-hemolytic streptococci, Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae, Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa and Candida albicans. Time-kill curves were assessed for susceptible microorganisms, testing 0, 0.5, 1, 2, 4 x MIC for propolis, by counting viable bacteria after 0, 3, 6, 24 hours and viable yeasts after 0, 3, 6, 24 and 48 hours. Propolis showed good antimicrobial activity against most of the isolates, particularly S. pneumoniae, H. influenzae and M. catarrhalis, but not against Enterobacteriaceae. Time-kill curves demonstrated bacteriostatic rather than bactericidal activity of propolis, the latter being evident only at high concentrations.

Citing Articles

Investigation of biocompatibility and antibacterial properties of electrospun chitosan/ polyethylene oxide -based scaffolds containing propolis extract against , , and .

Ebrahimi S, Nikbakht M, Shahini Shams Abadi M, Gholipour A, Bagheri M, Validi M Heliyon. 2025; 11(3):e42228.

PMID: 39944333 PMC: 11815904. DOI: 10.1016/j.heliyon.2025.e42228.


Propolis mouthwashes efficacy in managing gingivitis and periodontitis: a systematic review of the latest findings.

Ballouk M, Altinawi M, Al-Kafri A, Zeitounlouian T, Fudalej P BDJ Open. 2025; 11(1):5.

PMID: 39863575 PMC: 11763050. DOI: 10.1038/s41405-025-00294-z.


In vitro and in vivo burn healing study of standardized propolis: Unveiling its antibacterial, antioxidant and anti-inflammatory actions in relation to its phytochemical profiling.

El-Kersh D, Abou El-Ezz R, Ramadan E, El-Kased R PLoS One. 2024; 19(5):e0302795.

PMID: 38743731 PMC: 11093344. DOI: 10.1371/journal.pone.0302795.


Cell wall disruption, membrane damage, and decrease in the expression of Yrp1 virulence factor in by propolis ethanol extract.

Sheydai F, Tukmechi A Iran J Microbiol. 2023; 15(4):533-540.

PMID: 38045706 PMC: 10692965. DOI: 10.18502/ijm.v15i4.13507.


In Vitro Antibiofilm Effect of N-Acetyl-L-cysteine/Dry Propolis Extract Combination on Bacterial Pathogens Isolated from Upper Respiratory Tract Infections.

Bozic D, Cirkovic I, Milovanovic J, Bufan B, Folic M, Savic Vujovic K Pharmaceuticals (Basel). 2023; 16(11).

PMID: 38004469 PMC: 10674846. DOI: 10.3390/ph16111604.