Fetal Origins of Adult Disease: Epidemiology and Mechanisms

Overview

Journal J Clin Pathol

Specialty Pathology

Date 2000 Dec 29

PMID 11127263

Citations 18

Authors

C D Byrne

D I Phillips

Affiliations

Soon will be listed here.

Abstract

The past 10 years have provided unequivocal evidence that there are associations between birth size measures and future development of adult diseases, such as type 2 diabetes and coronary artery disease. Despite initial concern that bias or residual confounding in the analyses had produced these rather bizarre associations, the findings have now been reproduced in different cohorts by independent investigators from many parts of the world. The challenge for the next decade must be to discover the cellular and molecular mechanisms giving rise to these associations. If this aim is accomplished, it might be possible to devise strategies to reduce the impact of these disabling, chronic, and expensive diseases. The purpose of this review is to describe some of the relevant, important, and more recent epidemiological studies, and also to discuss potential mechanisms underpinning the associations.

Citing Articles

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References

Zhang J, Desai M, Ozanne S, Doherty C, Hales C, Byrne C . Two variants of quantitative reverse transcriptase PCR used to show differential expression of alpha-, beta- and gamma-fibrinogen genes in rat liver lobes. Biochem J. 1997; 321 ( Pt 3):769-75. PMC: 1218134. DOI: 10.1042/bj3210769. View

Poulsen P, Vaag A, Kyvik K, Moller Jensen D, Beck-Nielsen H . Low birth weight is associated with NIDDM in discordant monozygotic and dizygotic twin pairs. Diabetologia. 1997; 40(4):439-46. DOI: 10.1007/s001250050698. View

Langley-Evans S . Intrauterine programming of hypertension by glucocorticoids. Life Sci. 1997; 60(15):1213-21. DOI: 10.1016/s0024-3205(96)00611-x. View

Robson E . Birth weight in cousins. Ann Hum Genet. 1955; 19(4):262-8. DOI: 10.1111/j.1469-1809.1955.tb01352.x. View

Forsen T, Eriksson J, Tuomilehto J, Teramo K, Osmond C, Barker D . Mother's weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ. 1997; 315(7112):837-40. PMC: 2127571. DOI: 10.1136/bmj.315.7112.837. View

Zhang J, Byrne C . Differential hepatic lobar gene expression in offspring exposed to altered maternal dietary protein intake. Am J Physiol Gastrointest Liver Physiol. 2000; 278(1):G128-36. DOI: 10.1152/ajpgi.2000.278.1.G128. View

Flanagan D, Moore V, Godsland I, Cockington R, Robinson J, Phillips D . Fetal growth and the physiological control of glucose tolerance in adults: a minimal model analysis. Am J Physiol Endocrinol Metab. 2000; 278(4):E700-6. DOI: 10.1152/ajpendo.2000.278.4.E700. View

Edelstone D, Rudolph A, Heymann M . Liver and ductus venosus blood flows in fetal lambs in utero. Circ Res. 1978; 42(3):426-33. DOI: 10.1161/01.res.42.3.426. View

Clausen J, Borch-Johnsen K, Pedersen O . Relation between birth weight and the insulin sensitivity index in a population sample of 331 young, healthy Caucasians. Am J Epidemiol. 1997; 146(1):23-31. DOI: 10.1093/oxfordjournals.aje.a009188. View

10.

Barker D, WINTER P, Osmond C, Margetts B, Simmonds S . Weight in infancy and death from ischaemic heart disease. Lancet. 1989; 2(8663):577-80. DOI: 10.1016/s0140-6736(89)90710-1. View

11.

Rich-Edwards J, Stampfer M, Manson J, Rosner B, Hankinson S, Colditz G . Birth weight and risk of cardiovascular disease in a cohort of women followed up since 1976. BMJ. 1997; 315(7105):396-400. PMC: 2127275. DOI: 10.1136/bmj.315.7105.396. View

12.

Burns S, Desai M, Cohen R, Hales C, Iles R, Germain J . Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J Clin Invest. 1997; 100(7):1768-74. PMC: 508361. DOI: 10.1172/JCI119703. View

13.

Stanner S, Bulmer K, Andres C, Lantseva O, Borodina V, Poteen V . Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. BMJ. 1997; 315(7119):1342-8. PMC: 2127836. DOI: 10.1136/bmj.315.7119.1342. View

14.

Ravelli A, van der Meulen J, Michels R, Osmond C, Barker D, Hales C . Glucose tolerance in adults after prenatal exposure to famine. Lancet. 1998; 351(9097):173-7. DOI: 10.1016/s0140-6736(97)07244-9. View

15.

Phillips D, Barker D, Fall C, Seckl J, Whorwood C, Wood P . Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome?. J Clin Endocrinol Metab. 1998; 83(3):757-60. DOI: 10.1210/jcem.83.3.4634. View

16.

Dunger D, Ong K, Huxtable S, Sherriff A, Woods K, Ahmed M . Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Nat Genet. 1998; 19(1):98-100. DOI: 10.1038/ng0598-98. View

17.

Hattersley A, Beards F, Ballantyne E, Appleton M, Harvey R, Ellard S . Mutations in the glucokinase gene of the fetus result in reduced birth weight. Nat Genet. 1998; 19(3):268-70. DOI: 10.1038/953. View

18.

Phillips D . Birth weight and the future development of diabetes. A review of the evidence. Diabetes Care. 1998; 21 Suppl 2:B150-5. View

19.

McKeigue P, Lithell H, Leon D . Glucose tolerance and resistance to insulin-stimulated glucose uptake in men aged 70 years in relation to size at birth. Diabetologia. 1998; 41(10):1133-8. DOI: 10.1007/s001250051042. View

20.

Ong K, Phillips D, Fall C, Poulton J, Bennett S, Golding J . The insulin gene VNTR, type 2 diabetes and birth weight. Nat Genet. 1999; 21(3):262-3. DOI: 10.1038/6775. View