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Sexual Side Effects of Antidepressant Drugs

Overview
Publisher Current Science
Specialty Psychiatry
Date 2000 Dec 21
PMID 11122960
Citations 6
Authors
Affiliations
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Abstract

Sexual functioning often suffers during depression, although depressed people continue to value sex. Many popular antidepressants further impair sexual functioning, with highly serotonergic agents affecting orgasm and libido prominently. This paper addresses clinical assessment of sexual side effects from antidepressant drugs and reviews treatment strategies, including purported antidotes. We pay particular attention to sildenafil, on which there are impressive data and ongoing controlled studies.

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References
1.
Waldinger M, Hengeveld M, Zwinderman A, Olivier B . Effect of SSRI antidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline. J Clin Psychopharmacol. 1998; 18(4):274-81. DOI: 10.1097/00004714-199808000-00004. View

2.
Rosenberg K . Sildenafil citrate for SSRI-induced sexual side effects. Am J Psychiatry. 1999; 156(1):157. DOI: 10.1176/ajp.156.1.157. View

3.
Shen W, Urosevich Z, Clayton D . Sildenafil in the treatment of female sexual dysfunction induced by selective serotonin reuptake inhibitors. J Reprod Med. 1999; 44(6):535-42. View

4.
Monteiro W, Noshirvani H, Marks I, Lelliott P . Anorgasmia from clomipramine in obsessive-compulsive disorder. A controlled trial. Br J Psychiatry. 1987; 151:107-12. DOI: 10.1192/bjp.151.1.107. View

5.
Piazza L, Markowitz J, Kocsis J, Leon A, Portera L, Miller N . Sexual functioning in chronically depressed patients treated with SSRI antidepressants: a pilot study. Am J Psychiatry. 1997; 154(12):1757-9. DOI: 10.1176/ajp.154.12.1757. View