Postprandial Lipemia and Coronary Risk

Overview

Journal Curr Atheroscler Rep

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2000 Dec 21

PMID 11122749

Citations 4

Authors

W Patsch

H Esterbauer

B Foger

J R Patsch

Affiliations

Soon will be listed here.

Abstract

A number of cross-sectional studies have demonstrated that the magnitude of postprandial lipemia or single postprandial triglyceride values predict asymptomatic and symptomatic atherosclerosis, independent of risk factors measured in the fasting state. Postprandial lipemia reflects an integrated measure of an individual's triglyceride metabolic capacity. Numerous genetic and environmental factors that are known or suspected to affect triglyceride transport contribute to the magnitude of postprandial lipemia. In this article, mechanisms linking postprandial lipemia with the development and progression of atherosclerosis are described, and determinants of the extent and duration of postprandial lipemia are discussed.

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References

Cianflone K, Sniderman A, Walsh M, Vu H, Gagnon J, Rodriguez M . Purification and characterization of acylation stimulating protein. J Biol Chem. 1989; 264(1):426-30. View

Ritsch A, Drexel H, Amann F, Pfeifhofer C, Patsch J . Deficiency of cholesteryl ester transfer protein. Description of the molecular defect and the dissociation of cholesteryl ester and triglyceride transport in plasma. Arterioscler Thromb Vasc Biol. 1998; 17(12):3433-41. DOI: 10.1161/01.atv.17.12.3433. View

Olsson U, Camejo G, Hurt-Camejo E, Elfsber K, Wiklund O, Bondjers G . Possible functional interactions of apolipoprotein B-100 segments that associate with cell proteoglycans and the ApoB/E receptor. Arterioscler Thromb Vasc Biol. 1997; 17(1):149-55. DOI: 10.1161/01.atv.17.1.149. View

Li W, Dammerman M, Smith J, Metzger S, Breslow J, Leff T . Common genetic variation in the promoter of the human apo CIII gene abolishes regulation by insulin and may contribute to hypertriglyceridemia. J Clin Invest. 1995; 96(6):2601-5. PMC: 185964. DOI: 10.1172/JCI118324. View

Ito Y, Azrolan N, OConnell A, Walsh A, Breslow J . Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Science. 1990; 249(4970):790-3. DOI: 10.1126/science.2167514. View

Ahmed M, Gannon M, Nuttall F . Postprandial plasma glucose, insulin, glucagon and triglyceride responses to a standard diet in normal subjects. Diabetologia. 1976; 12(1):61-7. DOI: 10.1007/BF01221966. View

Dallongeville J, Tiret L, Visvikis S, OReilly D, Saava M, TSITOURIS G . Effect of apo E phenotype on plasma postprandial triglyceride levels in young male adults with and without a familial history of myocardial infarction: the EARS II study. European Atherosclerosis Research Study. Atherosclerosis. 1999; 145(2):381-8. DOI: 10.1016/s0021-9150(99)00069-6. View

Murray I, Sniderman A, Cianflone K . Enhanced triglyceride clearance with intraperitoneal human acylation stimulating protein in C57BL/6 mice. Am J Physiol. 1999; 277(3):E474-80. DOI: 10.1152/ajpendo.1999.277.3.E474. View

Humphries S, Nicaud V, Margalef J, Tiret L, Talmud P . Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS). Arterioscler Thromb Vasc Biol. 1998; 18(4):526-34. DOI: 10.1161/01.atv.18.4.526. View

10.

Mann C, Yen F, Grant A, Bihain B . Mechanism of plasma cholesteryl ester transfer in hypertriglyceridemia. J Clin Invest. 1991; 88(6):2059-66. PMC: 295801. DOI: 10.1172/JCI115535. View

11.

Foger B, Konigsrainer A, Ritsch A, Lechleitner M, Steurer W, Margreiter R . Pancreas transplantation modulates reverse cholesterol transport. Transpl Int. 1999; 12(5):360-4. DOI: 10.1007/s001470050240. View

12.

Baldo A, Sniderman A, Avramoglu R, Maslowska M, Hoang B, Monge J . The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis. J Clin Invest. 1993; 92(3):1543-7. PMC: 288301. DOI: 10.1172/JCI116733. View

13.

Miesenbock G, Holzl B, Foger B, Brandstatter E, Paulweber B, SANDHOFER F . Heterozygous lipoprotein lipase deficiency due to a missense mutation as the cause of impaired triglyceride tolerance with multiple lipoprotein abnormalities. J Clin Invest. 1993; 91(2):448-55. PMC: 287952. DOI: 10.1172/JCI116222. View

14.

Inazu A, Brown M, Hesler C, Agellon L, Koizumi J, Takata K . Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. N Engl J Med. 1990; 323(18):1234-8. DOI: 10.1056/NEJM199011013231803. View

15.

Reardon M, FIDGE N, Nestel P . Catabolism of very low density lipoprotein B apoprotein in man. J Clin Invest. 1978; 61(3):850-60. PMC: 372600. DOI: 10.1172/JCI108999. View

16.

Schneider W, Kovanen P, Brown M, Goldstein J, Utermann G, Weber W . Familial dysbetalipoproteinemia. Abnormal binding of mutant apoprotein E to low density lipoprotein receptors of human fibroblasts and membranes from liver and adrenal of rats, rabbits, and cows. J Clin Invest. 1981; 68(4):1075-85. PMC: 370895. DOI: 10.1172/jci110330. View

17.

Denborough M . ALIMENTARY LIPAEMIA IN ISCHAEMIC HEART DISEASE. Clin Sci. 1963; 25:115-22. View

19.

Agren J, Valve R, Vidgren H, Laakso M, Uusitupa M . Postprandial lipemic response is modified by the polymorphism at codon 54 of the fatty acid-binding protein 2 gene. Arterioscler Thromb Vasc Biol. 1998; 18(10):1606-10. DOI: 10.1161/01.atv.18.10.1606. View

20.

Tauber J, Cheng J, GOSPODAROWICZ D . Effect of high and low density lipoproteins on proliferation of cultured bovine vascular endothelial cells. J Clin Invest. 1980; 66(4):696-708. PMC: 371644. DOI: 10.1172/JCI109907. View

21.

Murray I, Sniderman A, Cianflone K . Mice lacking acylation stimulating protein (ASP) have delayed postprandial triglyceride clearance. J Lipid Res. 1999; 40(9):1671-6. View