Multi-exponential Analysis of Plasma Free Amino Acid Kinetics in the Rat

A multi-exponential analysis has been made of the curve of decreasing specific radioactivity with time after intravenous injection of a mixture of (U-14C)-labelled amino acids in rats. The data were shown to accord well with a linear model which was tested using an approximate linear regression method. This confirmed the satisfactory fit of the data to the model. Values for total entry into and of irreversible disposal from plasma were calculated and the extent of external recycling of amino acids obtained by difference.