Pathophysiology of Subendocardial Ischaemia

Overview

Journal Br Med J

Specialty General Medicine

Date 1975 Jan 11

PMID 1109663

Citations 19

Authors

J I Hoffman

G D Buckberg

Affiliations

Soon will be listed here.

Abstract

Most forms of heart disease cause myocardial damage which often is confined to the deep (subendocardial) layer of left ventricular muscle. Much clinical and experimental evidence suggests that subendocardial muscle is prone to ischaemic damage, and a physiological mechanism for this vulnerability is described. Furthermore, experiments suggest that pressures recorded at cardiac catheterization can help to assess if there is subendocardial ischaemia in a variety of lesions in man.

Citing Articles

Prerequisite endocardial-mesenchymal transition for murine cardiac trabecular angiogenesis.

Lu P, Wu B, Wang Y, Russell M, Liu Y, Bernard D Dev Cell. 2023; 58(9):791-805.e4.

PMID: 37023750 PMC: 10656710. DOI: 10.1016/j.devcel.2023.03.009.

Comparing Door-To-Balloon Time between ST-Elevation Myocardial Infarction Electrocardiogram and Its Equivalents.

Choi Y, Kim K, Oh J, Jeong H, Park J, Kyong Y J Clin Med. 2022; 11(19).

PMID: 36233413 PMC: 9570598. DOI: 10.3390/jcm11195547.

Reversed Apico-Basal Myocardial Relaxation Sequence During Exercise in Long QT Syndrome Mutations Carriers With History of Previous Cardiac Events.

Charisopoulou D, Koulaouzidis G, Rydberg A, Henein M Front Physiol. 2022; 12:780448.

PMID: 35197859 PMC: 8859439. DOI: 10.3389/fphys.2021.780448.

Comparison Between Invasive and Noninvasive Methods to Estimate Subendocardial Oxygen Supply and Demand Imbalance.

Salvi P, Baldi C, Scalise F, Grillo A, Salvi L, Tan I J Am Heart Assoc. 2021; 10(17):e021207.

PMID: 34465133 PMC: 8649295. DOI: 10.1161/JAHA.121.021207.

Exercise Induced Worsening of Mechanical Heterogeneity and Diastolic Impairment in Long QT Syndrome.

Charisopoulou D, Koulaouzidis G, Law L, Rydberg A, Henein M J Clin Med. 2020; 10(1).

PMID: 33374442 PMC: 7795719. DOI: 10.3390/jcm10010037.

References

MCDONALD Jr R, Taylor R, Cingolani H . Measurement of myocardial developed tension and its relation to oxygen consumption. Am J Physiol. 1966; 211(3):667-73. DOI: 10.1152/ajplegacy.1966.211.3.667. View

MOLLER J, Nakib A, Edwards J . Infarction of papillary muscles and mitral insufficiency associated with congenital aortic stenosis. Circulation. 1966; 34(1):87-91. DOI: 10.1161/01.cir.34.1.87. View

SARNOFF S, Braunwald E, WELCH Jr G, CASE R, STAINSBY W, Macruz R . Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension-time index. Am J Physiol. 1958; 192(1):148-56. DOI: 10.1152/ajplegacy.1957.192.1.148. View

FULTON W . ANASTOMOTIC ENLARGEMENT AND ISCHAEMIC MYOCARDIAL DAMAGE. Br Heart J. 1964; 26:1-15. PMC: 1018078. DOI: 10.1136/hrt.26.1.1. View

HACKEL D, MARTIN Jr A, SPACH M, SIEKER H . HEMORRHAGIC SHOCK IN DOGS. RELATION OF HEMODYNAMIC AND METABOLIC CHANGES TO MYOCARDIAL LESIONS. Arch Pathol. 1964; 77:575-81. View

Ferrans V, HIBBS R, Black W, WEILBAECHER D . ISOPROTERENOL-INDUCED MYOCARDIAL NECROSIS. A HISTOCHEMICAL AND ELECTRON MICROSCOPIC STUDY. Am Heart J. 1964; 68:71-90. DOI: 10.1016/0002-8703(64)90242-x. View

ROWE G, Afonso S, Lugo J, Castillo C, BOAKE W, CRUMPTON C . CORONARY BLOOD FLOW AND MYOCARDIAL OXIDATIVE METABOLISM AT REST AND DURING EXERCISE IN SUBJECTS WITH SEVERE AORTIC VALVE DISEASE. Circulation. 1965; 32:251-7. DOI: 10.1161/01.cir.32.2.251. View

MASTER A, Dack S, Horn H, Freedman B, FIELD L . Acute coronary insufficiency due to acute hemorrhage: an analysis of 103 cases. Circulation. 1950; 1(6):1302-17. DOI: 10.1161/01.cir.1.6.1302. View

Fallen E, ELLIOTT W, Gorlin R . Mechanisms of angina in aortic stenosis. Circulation. 1967; 36(4):480-8. DOI: 10.1161/01.cir.36.4.480. View

10.

Moir T, DEBRA D . Effect of left ventricular hypertension, ischemia and vasoactive drugs on the myocardial distribution of coronary flow. Circ Res. 1967; 21(1):65-74. DOI: 10.1161/01.res.21.1.65. View

11.

Brandi G, McGregor M . Intramural pressure in the left ventricle of the dog. Cardiovasc Res. 1969; 3(4):472-5. DOI: 10.1093/cvr/3.4.472. View

12.

Baird R, Manktelow R, Shah P, Ameli F . Intramyocardial pressure. A study of its regional variations and its relationship to intraventricular pressure. J Thorac Cardiovasc Surg. 1970; 59(6):810-23. View

13.

HARVEY W, Segal J, HUFNAGEL C . Unusual clinical features associated with severe aortic insufficiency. Ann Intern Med. 1957; 47(1):27-38. DOI: 10.7326/0003-4819-47-1-27. View

14.

Miller R, Burchell H, Edwards J . Myocardial infarction with and without acute coronary occlusion; a pathologic study. AMA Arch Intern Med. 1951; 88(5):597-604. DOI: 10.1001/archinte.1951.03810110049005. View

15.

Najafi H, Henson D, Dye W, JAVID H, Hunter J, Callaghan R . Left ventricular hemorrhagic necrosis. Ann Thorac Surg. 1969; 7(6):550-61. DOI: 10.1016/s0003-4975(10)66395-3. View

16.

Brazier J, Cooper N, Buckberg G . The adequacy of subendocardial oxygen delivery: the interaction of determinants of flow, arterial oxygen content and myocardial oxygen need. Circulation. 1974; 49(5):968-77. DOI: 10.1161/01.cir.49.5.968. View

17.

Lewis A, Heymann M, Stanger P, Hoffman J, Rudolph A . Evaluation of subendocardial ischemia in valvar aortic stenosis in children. Circulation. 1974; 49(5):978-84. DOI: 10.1161/01.cir.49.5.978. View

18.

Vincent W, Buckberg G, Hoffman J . Left ventricular subendocardial ischemia in severe valvar and supravalvar aortic stenosis. A common mechanism. Circulation. 1974; 49(2):326-33. DOI: 10.1161/01.cir.49.2.326. View

19.

Buckberg G, Ross G . Effects of isoprenaline on coronary blood flow: its distribution and myocardial performance. Cardiovasc Res. 1973; 7(4):429-37. DOI: 10.1093/cvr/7.4.429. View

20.

Barnard R, MACALPIN R, Kattus A, Buckberg G . Ischemic response to sudden strenuous exercise in healthy men. Circulation. 1973; 48(5):936-42. DOI: 10.1161/01.cir.48.5.936. View