» Articles » PMID: 11095829

Viral Load Monitoring in HIV Infection

Overview
Date 2000 Nov 30
PMID 11095829
Authors
Affiliations
Soon will be listed here.
Abstract

Measurement of HIV-1 viral load is now an accepted part of clinical practice for the determination of clinical prognosis and antiretroviral effectiveness in HIV infection. Consensus guidelines have been published on the appropriate use of this testing. Furthermore, recent advances in molecular technology have improved the sensitivity and reproducibility of viral load assays, and these improved assays have provided new insight into the pathogenesis of HIV disease. This article reviews new issues affecting viral load quantification, including viral subtypes, sex, compartmental differences, and other covariables.

References
1.
. HIV-1 viral load and CD4 cell count in untreated children with vertically acquired asymptomatic or mild disease. Paediatric European Network for Treatment of AIDS (PENTA). AIDS. 1998; 12(4):F1-8. View

2.
Ogg G, Jin X, Bonhoeffer S, Dunbar P, Nowak M, Monard S . Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science. 1998; 279(5359):2103-6. DOI: 10.1126/science.279.5359.2103. View

3.
Donovan R, Moore E, Bush C, Markowitz N, Saravolatz L . Changes in plasma HIV RNA levels and CD4 cell counts after vaccination of pediatric patients. AIDS. 1997; 11(8):1054-6. View

4.
Luque A, Demeter L, Reichman R . Association of human papillomavirus infection and disease with magnitude of human immunodeficiency virus type 1 (HIV-1) RNA plasma level among women with HIV-1 infection. J Infect Dis. 1999; 179(6):1405-9. DOI: 10.1086/314754. View

5.
Min J, Katzenstein D . Detection of Kaposi's sarcoma-associated herpesvirus in peripheral blood cells in human immunodeficiency virus infection: association with Kaposi's sarcoma, CD4 cell count, and HIV RNA levels. AIDS Res Hum Retroviruses. 1999; 15(1):51-5. DOI: 10.1089/088922299311709. View