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An Approach to Multi-copy Search in Molecular Replacement

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Specialty Chemistry
Date 2000 Nov 28
PMID 11092928
Citations 313
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Abstract

The molecular-replacement method has been extended to a simultaneous search for multiple copies of the macromolecule in the unit cell. The central point of this approach is the construction of a multi-copy search model from the properly oriented monomers using a special translation function. The multi-copy search method has been implemented in the program MOLREP and successfully tested using experimental data.

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