Geminiviruses and the Plant Cell Cycle

Overview

Journal Plant Mol Biol

Date 2000 Nov 23

PMID 11089875

Citations 28

Authors

C Gutierrez

Affiliations

Soon will be listed here.

Abstract

Geminiviruses are plant DNA viruses with a small genome that infect a large variety of plant species. Viral proteins regulate viral DNA replication and transcription. Also they appear to have an impact on cellular gene expression. Cellular proteins directly involved in DNA replication, such as PCNA, have long been known to accumulate in cells expressing Rep tomato golden mosaic geminivirus. This effect can be a direct effect of the viral protein and/or be mediated by interference with the G1/S transition control, namely the pathway controlled by the retinoblastoma-related (RBR) protein, analogous to the human retinoblastoma (RB) tumour suppressor protein. Different geminiviruses seem to have evolved two mechanisms to interact with plant RBR proteins. One is dependent on a LxCxE amino acid motif present in proteins, such as RepA, encoded by members of the Mastrevirus genus, and another seems to be mediated by the viral Rep protein, which lacks the LxCxE motif, encoded by members of the Begomovirus, and perhaps the Curtovirus genus. These and other aspects of the relationships between geminivirus replication and cell cycle control pathways will be discussed.

Citing Articles

The Past, Present, and Future of Wheat Dwarf Virus Management-A Review.

Pfrieme A, Will T, Pillen K, Stahl A Plants (Basel). 2023; 12(20).

PMID: 37896096 PMC: 10609771. DOI: 10.3390/plants12203633.

Small RNA Profiling of Susceptible and Resistant Encoding Tomato Plants Upon Tomato Yellow Leaf Curl Virus Infection.

Voorburg C, Bai Y, Kormelink R Front Plant Sci. 2021; 12:757165.

PMID: 34868151 PMC: 8637622. DOI: 10.3389/fpls.2021.757165.

The GpIA7 effector from the potato cyst nematode Globodera pallida targets potato EBP1 and interferes with the plant cell cycle programme.

Coke M, Mantelin S, Thorpe P, Lilley C, Wright K, Shaw D J Exp Bot. 2021; .

PMID: 34310681 PMC: 8547150. DOI: 10.1093/jxb/erab353.

Detection of Begomovirus in chilli and tomato plants using functionalized gold nanoparticles.

Lavanya R, Arun V Sci Rep. 2021; 11(1):14203.

PMID: 34244585 PMC: 8271019. DOI: 10.1038/s41598-021-93615-9.

Sequence modification on demand: search and replace tools for precise gene editing in plants.

cermak T Transgenic Res. 2021; 30(4):353-379.

PMID: 34086167 DOI: 10.1007/s11248-021-00253-y.

References

Accotto G, Mullineaux P, Brown S, Marie D . Digitaria streak geminivirus replicative forms are abundant in S-phase nuclei of infected cells. Virology. 1993; 195(1):257-9. DOI: 10.1006/viro.1993.1369. View

Collin S, Gooding P, Mullineaux P, Fenoll C . The two nonstructural proteins from wheat dwarf virus involved in viral gene expression and replication are retinoblastoma-binding proteins. Virology. 1996; 219(1):324-9. DOI: 10.1006/viro.1996.0256. View

Ramirez-Parra E, Xie Q, Boniotti M, Gutierrez C . The cloning of plant E2F, a retinoblastoma-binding protein, reveals unique and conserved features with animal G(1)/S regulators. Nucleic Acids Res. 1999; 27(17):3527-33. PMC: 148597. DOI: 10.1093/nar/27.17.3527. View

Pipas J . Common and unique features of T antigens encoded by the polyomavirus group. J Virol. 1992; 66(7):3979-85. PMC: 241200. DOI: 10.1128/JVI.66.7.3979-3985.1992. View

Katul L, Maiss E, Vetten H . Sequence analysis of a faba bean necrotic yellows virus DNA component containing a putative replicase gene. J Gen Virol. 1995; 76 ( Pt 2):475-9. DOI: 10.1099/0022-1317-76-2-475. View

Xie Q, Guo H, Garcia J, Gutierrez C . GRAB proteins, novel members of the NAC domain family, isolated by their interaction with a geminivirus protein. Plant Mol Biol. 1999; 39(4):647-56. DOI: 10.1023/a:1006138221874. View

Gorbalenya A, Koonin E . Viral proteins containing the purine NTP-binding sequence pattern. Nucleic Acids Res. 1989; 17(21):8413-40. PMC: 335016. DOI: 10.1093/nar/17.21.8413. View

Settlage S, Miller A, Hanley-Bowdoin L . Interactions between geminivirus replication proteins. J Virol. 1996; 70(10):6790-5. PMC: 190723. DOI: 10.1128/JVI.70.10.6790-6795.1996. View

Xie Q, Gutierrez C . Identification and analysis of a retinoblastoma binding motif in the replication protein of a plant DNA virus: requirement for efficient viral DNA replication. EMBO J. 1995; 14(16):4073-82. PMC: 394486. DOI: 10.1002/j.1460-2075.1995.tb00079.x. View

10.

Hanley-Bowdoin L, Settlage S, Orozco B, Nagar S, Robertson D . Geminiviruses: models for plant DNA replication, transcription, and cell cycle regulation. Crit Rev Biochem Mol Biol. 2000; 35(2):105-40. View

11.

Gutierrez C . Organization of the cis-acting element required for wheat dwarf geminivirus DNA replication and visualization of a rep protein-DNA complex. Virology. 1998; 243(1):119-29. DOI: 10.1006/viro.1998.9037. View

12.

Soderbarg K, Magnusson G . Lytic functions of mutant polyomavirus large T-antigen with deletion of retinoblastoma protein-binding motif. Virology. 1993; 193(1):281-8. DOI: 10.1006/viro.1993.1123. View

13.

Doonan J, Fobert P . Conserved and novel regulators of the plant cell cycle. Curr Opin Cell Biol. 1998; 9(6):824-30. DOI: 10.1016/s0955-0674(97)80083-x. View

14.

Ilyina T, Koonin E . Conserved sequence motifs in the initiator proteins for rolling circle DNA replication encoded by diverse replicons from eubacteria, eucaryotes and archaebacteria. Nucleic Acids Res. 1992; 20(13):3279-85. PMC: 312478. DOI: 10.1093/nar/20.13.3279. View

15.

Laufs J, Traut W, Heyraud F, Matzeit V, Rogers S, Schell J . In vitro cleavage and joining at the viral origin of replication by the replication initiator protein of tomato yellow leaf curl virus. Proc Natl Acad Sci U S A. 1995; 92(9):3879-83. PMC: 42065. DOI: 10.1073/pnas.92.9.3879. View

16.

Weinberg R . The retinoblastoma protein and cell cycle control. Cell. 1995; 81(3):323-30. DOI: 10.1016/0092-8674(95)90385-2. View

17.

Castellano M, Gutierrez C . Initiation of DNA replication in a eukaryotic rolling-circle replicon: identification of multiple DNA-protein complexes at the geminivirus origin. J Mol Biol. 1999; 290(3):639-52. DOI: 10.1006/jmbi.1999.2916. View

18.

Lazarowitz , Beachy . Viral movement proteins as probes for intracellular and intercellular trafficking in plants . Plant Cell. 1999; 11(4):535-48. PMC: 144200. DOI: 10.1105/tpc.11.4.535. View

19.

Fontes E, Luckow V, Hanley-Bowdoin L . A geminivirus replication protein is a sequence-specific DNA binding protein. Plant Cell. 1992; 4(5):597-608. PMC: 160156. DOI: 10.1105/tpc.4.5.597. View

20.

Helin K . Regulation of cell proliferation by the E2F transcription factors. Curr Opin Genet Dev. 1998; 8(1):28-35. DOI: 10.1016/s0959-437x(98)80058-0. View