Seasonality of Birth in Children (0-14 Years) with Diabetes Mellitus Type 1 in Baden-Wuerttemberg, Germany

The aim of the study was to find out whether children with diabetes type 1 in Baden-Wuerttemberg present a pattern of seasonality in their month of birth. A cohort of 1,184 children and adolescents (0-14 years) diagnosed as having diabetes between January 1st, 1987 and June 30th, 1997 were included in the study. Monthly and seasonal patterns of birth of patients with diabetes were compared with the pattern of normal live births (n = 2,724,746) during the years 1972-1997 and the seasonality of onset of disease. Statistical analysis was made using Student's t-test to compare the means between four yearly seasons and single cosinor analysis for a period of 12 months. The children and adolescents with diabetes had a significantly different seasonality in month of birth pattern from that registered in the general population, demonstrating fewer births during the months April-June and July-September. This seasonality pattern also differs from those registered in Israel, Sardinia and Slovenia, in which the population with diabetes type 1 had most births during these months.