Adaptation of Membrane Lipids to Alcohols

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1976 Feb 1

PMID 1107328

Citations 109

Authors

L O Ingram

Affiliations

Soon will be listed here.

Abstract

The effects of alcohols of different chain lengths on the fatty acid composition of Escherichia coli K-12 have been examined. My results indicate that these cells radically change their fatty acid composition when grown in the presence of alcohols. These changes represent an adaptive membrane alteration compensating for the direct physicochemical interaction of alcohols with the membrane. Similar adaptive responses of membrane lipids are proposed as a possible biochemical basis for tolerance to alcohol and related drugs.

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References

Luria S, DELBRUCK M . Mutations of Bacteria from Virus Sensitivity to Virus Resistance. Genetics. 1943; 28(6):491-511. PMC: 1209226. DOI: 10.1093/genetics/28.6.491. View

FREEMAN C, West D . Complete separation of lipid classes on a single thin-layer plate. J Lipid Res. 1966; 7(2):324-7. View

DITTMER J, Lester R . A SIMPLE, SPECIFIC SPRAY FOR THE DETECTION OF PHOSPHOLIPIDS ON THIN-LAYER CHROMATOGRAMS. J Lipid Res. 1964; 5:126-7. View

KANFER J, Kennedy E . METABOLISM AND FUNCTION OF BACTERIAL LIPIDS. I. METABOLISM OF PHOSPHOLIPIDS IN ESCHERICHIA COLI B. J Biol Chem. 1963; 238:2919-22. View

Caldwell J, Sever P . The biochemical pharmacology of abused drugs. II. Alcohol and barbiturates. Clin Pharmacol Ther. 1974; 16(5 Part 1):737-49. DOI: 10.1002/cpt1974165part1737. View

Lieber C . Hepatic and metabolic effects of alcohol (1966 to 1973). Gastroenterology. 1973; 65(5):821-46. View

Newman L, Lutz M, Domino E . Delta9-tetrahydrocannabinol and some CNS depressants: evidence for cross-tolerance in the rat. Arch Int Pharmacodyn Ther. 1974; 207(2):254-9. View

Woods J, Winger G . Alcoholism and animals. Prev Med. 1974; 3(1):49-60. DOI: 10.1016/0091-7435(74)90062-0. View

Grisham C, Barnett R . The interrelationship of membrane and protein structure in the functioning of the (Na + = K + )-activated ATPase. Biochim Biophys Acta. 1972; 266(3):613-24. DOI: 10.1016/0006-3002(72)90005-4. View

10.

Rubin E, Lieber C . Alcoholism, alcohol, and drugs. Science. 1971; 172(3988):1097-102. DOI: 10.1126/science.172.3988.1097. View

11.

Ingram L, Fisher W . Stimulation of cell division by membrane-active agents. Biochem Biophys Res Commun. 1973; 50(2):200-10. DOI: 10.1016/0006-291x(73)90827-9. View

12.

Hui F, Barton P . Mesomorphic behaviour of some phospholipids with aliphatic alcohols and other non-ionic substances. Biochim Biophys Acta. 1973; 296(3):510-7. DOI: 10.1016/0005-2760(73)90111-2. View

13.

Grisham C, Barnett R . The effects of long-chain alcohols on membrane lipids and the (Na++K+)-ATPase. Biochim Biophys Acta. 1973; 311(3):417-22. DOI: 10.1016/0005-2736(73)90322-2. View

14.

Sinensky M . Temperature control of phospholipid biosynthesis in Escherichia coli. J Bacteriol. 1971; 106(2):449-55. PMC: 285116. DOI: 10.1128/jb.106.2.449-455.1971. View

15.

Hubbell W, Metcalfe J, Metcalfe S, McConnell H . The interaction of small molecules with spin-labelled erythrocyte membranes. Biochim Biophys Acta. 1970; 219(2):415-27. DOI: 10.1016/0005-2736(70)90219-1. View

16.

Grisham C, Barnett R . The role of lipid-phase transitions in the regulation of the (sodium + potassium) adenosine triphosphatase. Biochemistry. 1973; 12(14):2635-7. DOI: 10.1021/bi00738a013. View

17.

Cronan Jr J . Regulation of the fatty acid composition of the membrane phospholipids of Escherichia coli. Proc Natl Acad Sci U S A. 1974; 71(9):3758-62. PMC: 433856. DOI: 10.1073/pnas.71.9.3758. View

18.

FULCO A . Metabolic alterations of fatty acids. Annu Rev Biochem. 1974; 43(0):215-41. DOI: 10.1146/annurev.bi.43.070174.001243. View

19.

SILBERT D, Ladenson R, Honegger J . The unsaturated fatty acid requirement in Escherichia coli. Temperature dependence and total replacement by branched-chain fatty acids. Biochim Biophys Acta. 1973; 311(3):349-61. DOI: 10.1016/0005-2736(73)90315-5. View

20.

Sheetz M, Singer S . Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions. Proc Natl Acad Sci U S A. 1974; 71(11):4457-61. PMC: 433905. DOI: 10.1073/pnas.71.11.4457. View