Article: Influence of time of infection during pregnancy with coxsackievirus B3 on maternal pathology and foetal growth in mice

Coxsackievirus B3 causes foetal wastage and growth retardation in mice which may be attributed to the action of the virus in destroying the maternal exocrine pancreas. Injection of virus on Day 4 or 8 of gestation caused greater foetal wastage than injection at 12 days. Foetal and placental weights in infected animals were less than in the controls but did not vary according to the time of infection. Little support is offered for the view that the mouse foetus differs in its susceptibility to Coxsackievirus B3 according to the stage in gestation of infection.

Citing Articles

Pancreas of coxsackievirus-infected dams and their challenged pups: A complex issue.

Sarmirova S, Borsanyiova M, Benkoova B, Pospisilova M, Arumugam R, Berakova K Virulence. 2019; 10(1):207-221.

PMID: 30829107 PMC: 6550550. DOI: 10.1080/21505594.2019.1589364.

Coxsackievirus B4 vertical transmission in a murine model.

Jaidane H, Halouani A, Jmii H, Elmastour F, Mokni M, Aouni M Virol J. 2017; 14(1):16.

PMID: 28143615 PMC: 5282869. DOI: 10.1186/s12985-017-0689-5.

In-utero coxsackievirus B4 infection of the mouse thymus.

Jaidane H, Halouani A, Jmii H, Elmastour F, Abdelkefi S, Bodart G Clin Exp Immunol. 2016; 187(3):399-407.

PMID: 27790717 PMC: 5290239. DOI: 10.1111/cei.12893.

Pregnancy loss following coxsackievirus b3 infection in mice during early gestation due to high expression of coxsackievirus-adenovirus receptor (CAR) in uterus and embryo.

Hwang J, Lee K, Kim Y, Shim H, Bae Y, Hwang J Exp Anim. 2014; 63(1):63-72.

PMID: 24521864 PMC: 4160930. DOI: 10.1538/expanim.63.63.

Pathological changes in pregnant mice infected with Coxsackievirus B3 and given dietary casein hydrolysate supplement.

Lansdown A Br J Exp Pathol. 1975; 56(4):373-6.

PMID: 1174463 PMC: 2072754.

References

1.

Coid C, Wardman G . The effect of para-influenza type 1 (Sendai) virus infection on early pregnancy in the rat. J Reprod Fertil. 1971; 24(1):39-43. DOI: 10.1530/jrf.0.0240039. View

2.

Coid C, Wardman G . The effect of maternal respiratory disease induced by para-influenza type 1 (Sendai) virus on foetal development and neonatal mortality in the rat. Med Microbiol Immunol. 1972; 157(3):181-5. DOI: 10.1007/BF02121160. View

3.

Catalano Jr L, Sever J . The role of viruses as causes of congenital diseases. Annu Rev Microbiol. 1971; 25:255-82. DOI: 10.1146/annurev.mi.25.100171.001351. View

4.

FUCCILLO D, Sever J . Viral teratology. Bacteriol Rev. 1973; 37(1):19-31. PMC: 413802. DOI: 10.1128/br.37.1.19-31.1973. View

5.

Lansdorn A, Ellaby S . Histochemical demonstration of changes in liver cell enzymes in pregnant mice infected with Coxsackie B3 virus. Histochemistry. 1974; 40(2):175-80. DOI: 10.1007/BF00495965. View

6.

PAPPENHEIMER A, KUNZ L, Richardson S . Passage of Coxsackie virus (Connecticut-5 strain) in adult mice with production of pancreatic disease. J Exp Med. 1951; 94(1):45-64. PMC: 2136094. DOI: 10.1084/jem.94.1.45. View

7.

Coid C, Ramsden D . Retardation of foetal growth and plasma protein development in foetuses from mice injected with Coxsackie B3 virus. Nature. 1973; 241(5390):460-1. DOI: 10.1038/241460a0. View

8.

Siegel M . Congenital malformations following chickenpox, measles, mumps, and hepatitis. Results of a cohort study. JAMA. 1973; 226(13):1521-4. View

9.

Lansdown A, Coid C . Pathological changes in pregnant mice infected with Coxsackie B3 virus as a possible cause of retarded foetal development. Br J Exp Pathol. 1974; 55(2):101-9. PMC: 2072521. View

10.

DALLDORF G, Gifford R . Susceptibility of gravid mice to Coxsackie virus infection. J Exp Med. 1954; 99(1):21-7. PMC: 2136322. DOI: 10.1084/jem.99.1.21. View

11.

Coleman T, GAMBLE D, Taylor K . Diabetes in mice after Coxsackie B 4 virus infection. Br Med J. 1973; 3(5870):25-7. PMC: 1587954. DOI: 10.1136/bmj.3.5870.25. View

Influence of Time of Infection During Pregnancy with Coxsackievirus B3 on Maternal Pathology and Foetal Growth in Mice