Antibody Regulation of B Cell Development

Overview

Journal Nat Immunol

Date 2001 Mar 23

PMID 11062496

Citations 85

Authors

E Meffre

R Casellas

M C Nussenzweig

Affiliations

Soon will be listed here.

Abstract

Antibodies on the surface of B lymphocytes trigger adaptive immune responses and control a series of antigen-independent checkpoints during B cell development. These physiologic processes are regulated by a complex of membrane immunoglobulin and two signal transducing proteins known as Ig alpha and Ig beta. Here we focus on the role of antibodies in governing the maturation of B cells from early antigen-independent through the final antigen-dependent stages.

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