Sensory Deprivation Without Competition Yields Modest Alterations of Short-term Synaptic Dynamics

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2000 Nov 1

PMID 11058162

Citations 11

Authors

G T Finnerty

B W Connors

Affiliations

Soon will be listed here.

Abstract

Cortical maps express experience-dependent plasticity. However, the underlying cellular mechanisms remain unclear. We have recently shown that sensory deprivation results in large changes of the short-term dynamics of excitatory synapses at the junction of deprived and spared somatosensory (barrel) cortex, which may contribute to map reorganization. A key issue is whether the alterations in short-term synaptic dynamics are driven by a loss of sensory input or by competition between deprived and spared inputs. Here, we report that short-term dynamics of horizontal pathways in the middle of uniformly deprived cortex change only modestly. Vertical intracortical pathways were unaffected by deprivation. Our results suggest that uniform loss of sensory activity has a limited effect on short-term synaptic dynamics. We concluded that competition between sensory inputs is necessary to produce large-scale changes in synaptic dynamics after sensory deprivation.

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References

Robertson D, Irvine D . Plasticity of frequency organization in auditory cortex of guinea pigs with partial unilateral deafness. J Comp Neurol. 1989; 282(3):456-71. DOI: 10.1002/cne.902820311. View

Stryker M, Harris W . Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex. J Neurosci. 1986; 6(8):2117-33. PMC: 6568765. View

Miller K, Keller J, Stryker M . Ocular dominance column development: analysis and simulation. Science. 1989; 245(4918):605-15. DOI: 10.1126/science.2762813. View

Kaas J, Krubitzer L, Chino Y, Langston A, POLLEY E, Blair N . Reorganization of retinotopic cortical maps in adult mammals after lesions of the retina. Science. 1990; 248(4952):229-31. DOI: 10.1126/science.2326637. View

Calford M, Tweedale R . Interhemispheric transfer of plasticity in the cerebral cortex. Science. 1990; 249(4970):805-7. DOI: 10.1126/science.2389146. View

Koralek K, OLAVARRIA J, Killackey H . Areal and laminar organization of corticocortical projections in the rat somatosensory cortex. J Comp Neurol. 1990; 299(2):133-50. DOI: 10.1002/cne.902990202. View

Agmon A, Connors B . Thalamocortical responses of mouse somatosensory (barrel) cortex in vitro. Neuroscience. 1991; 41(2-3):365-79. DOI: 10.1016/0306-4522(91)90333-j. View

Fox K . A critical period for experience-dependent synaptic plasticity in rat barrel cortex. J Neurosci. 1992; 12(5):1826-38. PMC: 6575898. View

Diamond M, Armstrong-James M, Ebner F . Experience-dependent plasticity in adult rat barrel cortex. Proc Natl Acad Sci U S A. 1993; 90(5):2082-6. PMC: 46025. DOI: 10.1073/pnas.90.5.2082. View

10.

Diamond M, Huang W, Ebner F . Laminar comparison of somatosensory cortical plasticity. Science. 1994; 265(5180):1885-8. DOI: 10.1126/science.8091215. View

11.

Armstrong-James M, Diamond M, Ebner F . An innocuous bias in whisker use in adult rats modifies receptive fields of barrel cortex neurons. J Neurosci. 1994; 14(11 Pt 2):6978-91. PMC: 6577275. View

12.

Fox K . The cortical component of experience-dependent synaptic plasticity in the rat barrel cortex. J Neurosci. 1994; 14(12):7665-79. PMC: 6576872. View

13.

Kirkwood A, Lee H, Bear M . Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience. Nature. 1995; 375(6529):328-31. DOI: 10.1038/375328a0. View

14.

Hensch T, Stryker M . Ocular dominance plasticity under metabotropic glutamate receptor blockade. Science. 1996; 272(5261):554-7. DOI: 10.1126/science.272.5261.554. View

15.

Kirkwood A, Rioult M, Bear M . Experience-dependent modification of synaptic plasticity in visual cortex. Nature. 1996; 381(6582):526-8. DOI: 10.1038/381526a0. View

16.

Glazewski S, Fox K . Time course of experience-dependent synaptic potentiation and depression in barrel cortex of adolescent rats. J Neurophysiol. 1996; 75(4):1714-29. DOI: 10.1152/jn.1996.75.4.1714. View

17.

Clarey J, Tweedale R, Calford M . Interhemispheric modulation of somatosensory receptive fields: evidence for plasticity in primary somatosensory cortex. Cereb Cortex. 1996; 6(2):196-206. DOI: 10.1093/cercor/6.2.196. View

18.

Markram H, Tsodyks M . Redistribution of synaptic efficacy between neocortical pyramidal neurons. Nature. 1996; 382(6594):807-10. DOI: 10.1038/382807a0. View

19.

Miller K . Synaptic economics: competition and cooperation in synaptic plasticity. Neuron. 1996; 17(3):371-4. DOI: 10.1016/s0896-6273(00)80169-5. View

20.

Abbott L, Varela J, Sen K, Nelson S . Synaptic depression and cortical gain control. Science. 1997; 275(5297):220-4. DOI: 10.1126/science.275.5297.221. View