Cytokine, Activation Marker, and Chemokine Receptor Expression by Individual CD4(+) Memory T Cells in Rheumatoid Arthritis Synovium

Overview

Journal Arthritis Res

Specialty Rheumatology

Date 2000 Nov 1

PMID 11056676

Citations 23

Authors

T Nanki

P E Lipsky

Affiliations

Soon will be listed here.

Abstract

IL-10, IL-13, IFN-gamma, tumor necrosis factor (TNF)-alpha, LT-alpha, CD154, and TNF-related activation-induced cytokine (TRANCE) were expressed by 2-20% of rheumatoid arthritis (RA) synovial tissue CD4(+) memory T cells, whereas CD4(+) cells that produced IL-2, IL-4, or IL-6 were not detected. Expression of none of these molecules by individual CD4(+) cells correlated with the exception of TRANCE and IL-10, and TRANCE and TNF-alpha. A correlation between expression of IL-10 and CCR7, LT-alpha and CCR6, IFN-gamma and CCR5, and TRANCE and CXCR4 was also detected.

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