Influence of Energy Metabolism on the Repair of X-ray Damage in Living Cells. IV. Effects of 2-deoxy-D-glucose on the Repair Phenomena During Fractionated Irradiation of Yeast

Overview

Journal Radiat Environ Biophys

Specialties Biophysics
Environmental Health
Oncology
Radiology

Date 1975 Dec 4

PMID 1105651

Citations 1

Authors

V K Jain

W POHLIT

S C Purohit

Affiliations

Soon will be listed here.

Abstract

Inhibition of repair of sublethal and potentially lethal damage was observed in respiratory-deficient mutants of yeast during fractionated X-irradiation in the presence of equimolar concentrations of 2-deoxy-D-glucose and glucose in the growth medium. In the wild-type cells, on the other hand, an enhancement of repair of the potentially lethal damage was obtained under similar conditions. These results suggest, by analogy, that in higher organisms also, 2-deoxy-D-glucose may differentially inhibit the repair of radiation damage in hypoxic tumor cells while enhancement of repair processes could be expected in normal tissues.

Citing Articles

2-Deoxy-D-Glucose: A Novel Pharmacological Agent for Killing Hypoxic Tumor Cells, Oxygen Dependence-Lowering in Covid-19, and Other Pharmacological Activities.

Singh R, Gupta V, Kumar A, Singh K Adv Pharmacol Pharm Sci. 2023; 2023:9993386.

PMID: 36911357 PMC: 9998157. DOI: 10.1155/2023/9993386.

References

Hahn G, Rockwell S, Kallman R, Gordon L, FRINDEL E . Repair of potentially lethal damage in vivo in solid tumor cells after x-irradiation. Cancer Res. 1974; 34(2):351-4. View

van Steveninck J . Transport-associated phosphorylation of 2-deoxy-D-glucose in yeast. Biochim Biophys Acta. 1968; 163(3):386-94. DOI: 10.1016/0005-2736(68)90123-5. View

Elkind M, Sutton H . X-ray damage and recovery in mammalian cells in culture. Nature. 1959; 184:1293-5. DOI: 10.1038/1841293a0. View

Jain V, POHLIT W, Purohit S . Influence of energy metabolism on the repair of x-ray damage in living cells. 3. Effect of 2-deoxy-D-glucose on the liquid-holding reactivation in yeast. Biophysik. 1973; 10(2):137-42. DOI: 10.1007/BF01191239. View

HEREDIA C, DELAFUENTE G, SOLS A . METABOLIC STUDIES WITH 2-DEOXYHEXOSES. I. MECHANISMS OF INHIBITION OF GROWTH AND FERMENTATION IN BAKER'S YEAST. Biochim Biophys Acta. 1964; 86:216-23. DOI: 10.1016/0304-4165(64)90045-5. View

Hatanaka M, Augl C, Gilden R . Evidence for a functional change in the plasma membrane of murine sarcoma virus-infected mouse embryo cells. Transport and transport-associated phosphorylation of 14C-2-deoxy-D-glucose. J Biol Chem. 1970; 245(4):714-7. View

Patrick M, HAYNES R . DARK RECOVERY PHENOMENA IN YEAST. II. CONDITIONS THAT MODIFY THE RECOVERY PROCESS. Radiat Res. 1964; 23:564-79. View

Alper T, GILLIES N . Restoration of Escherichia coli strain B after irradiation: its dependence on suboptimal growth conditions. J Gen Microbiol. 1958; 18(2):461-72. DOI: 10.1099/00221287-18-2-461. View

Little J, Hahn G, FRINDEL E, TUBIANA M . Repair of potentially lethal radiation damage in vitro and in vivo. Radiology. 1973; 106(3):689-94. DOI: 10.1148/106.3.689. View

10.

Jain V, POHLIT W . Influence of energy metabolism on the repair of x-ray damage in living cells. II. Split-dose recovery, liquid-holding reactivation and division delay reversal in stationary populations of yeast. Biophysik. 1973; 9(2):155-65. DOI: 10.1007/BF01215854. View

11.

Kiefer J . The importance of cellular energy metabolism for the sparing effect of dose fractionation with electrons and ultra-violet light. Int J Radiat Biol Relat Stud Phys Chem Med. 1971; 20(4):325-36. DOI: 10.1080/09553007114551211. View

12.

THOMLINSON R, GRAY L . The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer. 1955; 9(4):539-49. PMC: 2073776. DOI: 10.1038/bjc.1955.55. View

13.

Bacchetti S, Mauro F . RECOVERY FROM SUBLETHAL X-RAY DAMAGE IN SURVIVING YEAST CELLS. Radiat Res. 1965; 25:103-14. View

14.

Bacchetti S, Cassandro M, Elli R, Falchetti R, Mauro F . Relationship between recovery from sublethal damage by dose fractionation and the restoration of viability after delayed plating in diploid Saccharomyces cerevisiae. Radiat Res. 1966; 29(2):295-315. View

15.

Kuroki T, Yamakawa S . Kinetics of uptake of 2-deoxy-D-glucose and 2-aminoisobutyric acid in chemically transformed cells. Int J Cancer. 1974; 13(2):240-5. DOI: 10.1002/ijc.2910130211. View