Regional Changes of Cyclic 3',5'-guanosine Monophosphate in the Spinal Cord of the Rabbit Following Brief Repeated Ischemic Insults

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2000 Oct 31

PMID 11055752

Citations 1

Authors

J Pavel

N Lukacova

J Marsala

Affiliations

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Abstract

The regional distribution of cyclic 3',5'-guanosine monophosphate was studied in the lumbosacral segments of the spinal cord of the rabbit under physiological conditions and following brief repeated sublethal ischemic insults. While the basal cGMP level in the gray matter was about 0.120 nmol cGMP/mg wet. wt., the level of cGMP in non-compartmentalized white matter was about half of this value. The highest level of cGMP in the compartmentalized gray matter was found in the dorsal horns, about 0.180 nmol cGMP/mg wet. wt., whereas the level of cGMP was greatly reduced in the ventral horns, reaching one half of the previous value. Multiple sublethal ischemic insults, repeated at 1-h intervals, caused a statistically significant decrease of cGMP in all gray matter regions. While the post-ischemic and post-reperfusion level of cGMP in the dorsal horns remained relatively high in comparison with the intermediate zone and ventral horns, the changes of cGMP level detected in the white matter columns differed considerably and resulted in a statistically significant cGMP increase in the dorsal and ventral columns and, vice versa, a statistically significant decrease of cGMP was found in the lateral columns.

Citing Articles

The regional changes of the catalytic NOS activity in the spinal cord of the rabbit after repeated sublethal ischemia.

Pavel J, Lukacova N, Marsala J, Marsala M Neurochem Res. 2001; 26(7):833-9.

PMID: 11565616 DOI: 10.1023/a:1011620320596.

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