Methylation of a Membrane Protein Involved in Bacterial Chemotaxis

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1975 Oct 1

PMID 1105570

Citations 101

Authors

E N Kort

M F Goy

S H Larsen

J Adler

Affiliations

Soon will be listed here.

Abstract

A protein methylation reaction involved in chemotaxis of Escherichia coli has been identified. The involvement of this reaction in chemotaxis in indicated by four lines of evidence. (a) The methylation reaction is altered in several classes of generally nonchemotactic mutants and is coreverted with the chemotaxis defects. (b) The methylation level of the protein is affected by chemotactic stimuli. (c) The transferred methyl group is derived from methionine and is labile, in accord with the known fact that chemotaxis requires a continuous supply of methionine. (d) Methylation is abnormal in various mutants having defective or missing flagella.

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