Single-molecule X-ray Diffraction

Overview

Journal Curr Opin Struct Biol

Date 2000 Oct 24

PMID 11042456

Citations 16

Authors

J Hajdu

Affiliations

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Abstract

Free-electron lasers could provide femtosecond X-ray flashes with a peak brilliance 10-11 orders of magnitude higher than that which is currently available from synchrotrons. Such pulses may allow structural studies of single biomolecules before radiation damage destroys them and may permit the imaging of complex structures without the need to amplify scattered radiation through Bragg reflections.

Citing Articles

Bayesian electron density determination from sparse and noisy single-molecule X-ray scattering images.

Schultze S, Grubmuller H Sci Adv. 2024; 10(43):eadp4425.

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Single-Molecule X-ray Scattering Used to Visualize the Conformation Distribution of Biological Molecules via Single-Object Scattering Sampling.

Lee S, Ki H, Lee S, Ihee H Int J Mol Sci. 2023; 24(24).

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Are the Gas-Phase Structures of Molecular Elephants Enduring or Ephemeral? Results from Time-Dependent, Tandem Ion Mobility.

Zercher B, Hong S, Roush A, Feng Y, Bush M Anal Chem. 2023; 95(25):9589-9597.

PMID: 37294019 PMC: 10549206. DOI: 10.1021/acs.analchem.3c01222.

Reconstruction of 3D density from solution scattering.

Grant T Methods Enzymol. 2023; 678:145-192.

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Single-particle imaging by x-ray free-electron lasers-How many snapshots are needed?.

Poudyal I, Schmidt M, Schwander P Struct Dyn. 2020; 7(2):024102.

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