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Proliferation of Glial Cells in Vivo Induced in the Neural Lobe of the Rat Pituitary by Lithium

Overview
Journal Cell Prolif
Date 2000 Oct 21
PMID 11041201
Citations 3
Authors
S Levine
A Saltzman
A W Klein
Affiliations
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Abstract

Lithium salts are widely used for treatment of psychiatric illness. Lithium also affects cell proliferation. During investigation of the effect of lithium chloride on the central nervous system (CNS) of nephrectomized rats, we noted numerous mitotic figures in the neural lobe of the pituitary. Morphologic criteria established that the mitotic cells were astrocytes, the supporting glial cells of the CNS, also known as pituicytes. Equimolar doses of chlorides of chemically related cations (sodium, potassium, rubidium) had no such effect.

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