Peptidyl Transferase: Ancient and Exiguous
Overview
Biology
Chemistry
Affiliations
The finding that the universal ribosomal peptidyl transferase is an RNA enzyme casts new light on its ancient origins, on the use of transition state analogues for ribozymes, and on the role of selection-amplification in studies of molecular evolution.
Widmann J, Stombaugh J, McDonald D, Chocholousova J, Gardner P, Iyer M RNA. 2012; 18(7):1319-27.
PMID: 22645380 PMC: 3383963. DOI: 10.1261/rna.032052.111.
Chiral histidine selection by D-ribose RNA.
Illangasekare M, Turk R, Peterson G, Lladser M, Yarus M RNA. 2010; 16(12):2370-83.
PMID: 20940341 PMC: 2995399. DOI: 10.1261/rna.2385310.
Nucleotides that are essential but not conserved; a sufficient L-tryptophan site in RNA.
Majerfeld I, Chocholousova J, Malaiya V, Widmann J, McDonald D, Reeder J RNA. 2010; 16(10):1915-24.
PMID: 20699302 PMC: 2941100. DOI: 10.1261/rna.2220210.
Multiple pattern matching: a Markov chain approach.
Lladser M, Betterton M, Knight R J Math Biol. 2007; 56(1-2):51-92.
PMID: 17668213 DOI: 10.1007/s00285-007-0109-3.
Evolutionary rates vary among rRNA structural elements.
Smit S, Widmann J, Knight R Nucleic Acids Res. 2007; 35(10):3339-54.
PMID: 17468501 PMC: 1904297. DOI: 10.1093/nar/gkm101.