Modeling Concurrent Binding of Multiple Molecular Species in Cell Adhesion

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 2000 Oct 12

PMID 11023890

Citations 13

Authors

C Zhu

T E Williams

Affiliations

Soon will be listed here.

Abstract

Cell adhesion provides not only physical linkage but also communication between the cell and its environment. As such, it is important to many cellular functions. Recently, the probability distribution of forming a low number of specific adhesive bonds in a short-duration contact has been described (Chesla et al., Biophys. J. , 1998, 75:1553-1572). This model assumes that binding occurs between a single receptor species and a single ligand species. However, cell adhesion molecules rarely work alone in physiological settings. To account for these in vivo situations, we extended the previous model to include concurrent interactions of multiple receptor-ligand species, introducing the concept of independent binding. Closed-form solutions have been obtained for cases where competition is absent or can be neglected. In two companion papers (Williams et al., Biophys. J., 2000, 79:1858-1866; 2000, 79:1867-1875), the model developed herein has been applied to analyze two sets of experiments designed such that the validity of the theory was also tested.

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References

Springer T . Adhesion receptors of the immune system. Nature. 1990; 346(6283):425-34. DOI: 10.1038/346425a0. View

Long M, Goldsmith H, Tees D, Zhu C . Probabilistic modeling of shear-induced formation and breakage of doublets cross-linked by receptor-ligand bonds. Biophys J. 1999; 76(2):1112-28. PMC: 1300061. DOI: 10.1016/S0006-3495(99)77276-0. View

von Andrian U, Chambers J, McEvoy L, Bargatze R, Arfors K, Butcher E . Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo. Proc Natl Acad Sci U S A. 1991; 88(17):7538-42. PMC: 52336. DOI: 10.1073/pnas.88.17.7538. View

Kaplanski G, Farnarier C, Tissot O, Pierres A, Benoliel A, Alessi M . Granulocyte-endothelium initial adhesion. Analysis of transient binding events mediated by E-selectin in a laminar shear flow. Biophys J. 1993; 64(6):1922-33. PMC: 1262526. DOI: 10.1016/S0006-3495(93)81563-7. View

Tees D, Coenen O, Goldsmith H . Interaction forces between red cells agglutinated by antibody. IV. Time and force dependence of break-up. Biophys J. 1993; 65(3):1318-34. PMC: 1225851. DOI: 10.1016/S0006-3495(93)81180-9. View

Cooper D, Butcher C, Berndt M, Vadas M . P-selectin interacts with a beta 2-integrin to enhance phagocytosis. J Immunol. 1994; 153(7):3199-209. View

Alon R, Hammer D, Springer T . Lifetime of the P-selectin-carbohydrate bond and its response to tensile force in hydrodynamic flow. Nature. 1995; 374(6522):539-42. DOI: 10.1038/374539a0. View

Springer T . Traffic signals on endothelium for lymphocyte recirculation and leukocyte emigration. Annu Rev Physiol. 1995; 57:827-72. DOI: 10.1146/annurev.ph.57.030195.004143. View

Simon S, Burns A, Taylor A, Gopalan P, Lynam E, Sklar L . L-selectin (CD62L) cross-linking signals neutrophil adhesive functions via the Mac-1 (CD11b/CD18) beta 2-integrin. J Immunol. 1995; 155(3):1502-14. View

10.

Li P, Selvaraj P, Zhu C . Analysis of competition binding between soluble and membrane-bound ligands for cell surface receptors. Biophys J. 1999; 77(6):3394-406. PMC: 1300611. DOI: 10.1016/S0006-3495(99)77171-7. View

11.

Chesla S, Li P, Nagarajan S, Selvaraj P, Zhu C . The membrane anchor influences ligand binding two-dimensional kinetic rates and three-dimensional affinity of FcgammaRIII (CD16). J Biol Chem. 2000; 275(14):10235-46. DOI: 10.1074/jbc.275.14.10235. View

12.

Williams T, Selvaraj P, Zhu C . Concurrent binding to multiple ligands: kinetic rates of CD16b for membrane-bound IgG1 and IgG2. Biophys J. 2000; 79(4):1858-66. PMC: 1301077. DOI: 10.1016/S0006-3495(00)76435-6. View

13.

Williams T, Nagarajan S, Selvaraj P, Zhu C . Concurrent and independent binding of Fcgamma receptors IIa and IIIb to surface-bound IgG. Biophys J. 2000; 79(4):1867-75. PMC: 1301078. DOI: 10.1016/S0006-3495(00)76436-8. View

14.

Cheng Y, Prusoff W . Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction. Biochem Pharmacol. 1973; 22(23):3099-108. DOI: 10.1016/0006-2952(73)90196-2. View

15.

Horovitz A, Levitzki A . An accurate method for determination of receptor-ligand and enzyme-inhibitor dissociation constants from displacement curves. Proc Natl Acad Sci U S A. 1987; 84(19):6654-8. PMC: 299141. DOI: 10.1073/pnas.84.19.6654. View

16.

McEver R, Cummings R . Perspectives series: cell adhesion in vascular biology. Role of PSGL-1 binding to selectins in leukocyte recruitment. J Clin Invest. 1997; 100(3):485-91. PMC: 508213. DOI: 10.1172/JCI119556. View

17.

Piper J, Swerlick R, Zhu C . Determining force dependence of two-dimensional receptor-ligand binding affinity by centrifugation. Biophys J. 1998; 74(1):492-513. PMC: 1299402. DOI: 10.1016/S0006-3495(98)77807-5. View

18.

Chesla S, Selvaraj P, Zhu C . Measuring two-dimensional receptor-ligand binding kinetics by micropipette. Biophys J. 1998; 75(3):1553-72. PMC: 1299830. DOI: 10.1016/S0006-3495(98)74074-3. View

19.

Lawrence M, Springer T . Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell. 1991; 65(5):859-73. DOI: 10.1016/0092-8674(91)90393-d. View