Toll-like Receptors: Molecular Mechanisms of the Mammalian Immune Response

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2000 Sep 30

PMID 11012747

Citations 47

Authors

H D Brightbill

R L Modlin

Affiliations

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References

WILLIAMS M, Rodriguez A, Kimbrell D, Eldon E . The 18-wheeler mutation reveals complex antibacterial gene regulation in Drosophila host defense. EMBO J. 1997; 16(20):6120-30. PMC: 1326296. DOI: 10.1093/emboj/16.20.6120. View

Seder R, Paul W . Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol. 1994; 12:635-73. DOI: 10.1146/annurev.iy.12.040194.003223. View

Stancovski I, Baltimore D . NF-kappaB activation: the I kappaB kinase revealed?. Cell. 1997; 91(3):299-302. DOI: 10.1016/s0092-8674(00)80413-4. View

Ohashi K, Burkart V, Flohe S, Kolb H . Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol. 2000; 164(2):558-61. DOI: 10.4049/jimmunol.164.2.558. View

Levashina E, Langley E, Green C, Gubb D, Ashburner M, Hoffmann J . Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila. Science. 1999; 285(5435):1917-9. DOI: 10.1126/science.285.5435.1917. View

Han J, Lee J, Bibbs L, Ulevitch R . A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science. 1994; 265(5173):808-11. DOI: 10.1126/science.7914033. View

Medzhitov R, Janeway Jr C . Innate immunity: impact on the adaptive immune response. Curr Opin Immunol. 1997; 9(1):4-9. DOI: 10.1016/s0952-7915(97)80152-5. View

Meng X, Khanuja B, Ip Y . Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor. Genes Dev. 1999; 13(7):792-7. PMC: 316597. DOI: 10.1101/gad.13.7.792. View

MacMicking J, NORTH R, LaCourse R, Mudgett J, Shah S, Nathan C . Identification of nitric oxide synthase as a protective locus against tuberculosis. Proc Natl Acad Sci U S A. 1997; 94(10):5243-8. PMC: 24663. DOI: 10.1073/pnas.94.10.5243. View

10.

Medzhitov R, Preston-Hurlburt P, Kopp E, Stadlen A, Chen C, Ghosh S . MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell. 1998; 2(2):253-8. DOI: 10.1016/s1097-2765(00)80136-7. View

11.

Iwanaga S . The limulus clotting reaction. Curr Opin Immunol. 1993; 5(1):74-82. DOI: 10.1016/0952-7915(93)90084-6. View

12.

Zhang Y, DOERFLER M, Lee T, Guillemin B, Rom W . Mechanisms of stimulation of interleukin-1 beta and tumor necrosis factor-alpha by Mycobacterium tuberculosis components. J Clin Invest. 1993; 91(5):2076-83. PMC: 288206. DOI: 10.1172/JCI116430. View

13.

Means T, Lien E, Yoshimura A, Wang S, Golenbock D, Fenton M . The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J Immunol. 1999; 163(12):6748-55. View

14.

Poltorak A, He X, Smirnova I, Liu M, Van Huffel C, Du X . Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998; 282(5396):2085-8. DOI: 10.1126/science.282.5396.2085. View

15.

Chan V, Mecklenbrauker I, Su I, Texido G, Leitges M, Carsetti R . The molecular mechanism of B cell activation by toll-like receptor protein RP-105. J Exp Med. 1998; 188(1):93-101. PMC: 2525555. DOI: 10.1084/jem.188.1.93. View

16.

Lemaitre B, Meister M, Govind S, Georgel P, Steward R, Reichhart J . Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila. EMBO J. 1995; 14(3):536-45. PMC: 398111. DOI: 10.1002/j.1460-2075.1995.tb07029.x. View

17.

Poltorak A, Smirnova I, He X, Liu M, Van Huffel C, McNally O . Genetic and physical mapping of the Lps locus: identification of the toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis. 1998; 24(3):340-55. DOI: 10.1006/bcmd.1998.0201. View

18.

Belvin M, Anderson K . A conserved signaling pathway: the Drosophila toll-dorsal pathway. Annu Rev Cell Dev Biol. 1996; 12:393-416. DOI: 10.1146/annurev.cellbio.12.1.393. View

19.

Cleveland M, Gorham J, MURPHY T, Tuomanen E, Murphy K . Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect Immun. 1996; 64(6):1906-12. PMC: 174015. DOI: 10.1128/iai.64.6.1906-1912.1996. View

20.

Radolf J, Norgard M, Brandt M, Isaacs R, Thompson P, Beutler B . Lipoproteins of Borrelia burgdorferi and Treponema pallidum activate cachectin/tumor necrosis factor synthesis. Analysis using a CAT reporter construct. J Immunol. 1991; 147(6):1968-74. View