New Virulence-activated and Virulence-repressed Genes Identified by Systematic Gene Inactivation and Generation of Transcriptional Fusions in Bordetella Pertussis

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2000 Sep 27

PMID 11004193

Citations 40

Authors

R Antoine

S Alonso

D Raze

L Coutte

S Lesjean

E Willery

C Locht

F Jacob-Dubuisson

Affiliations

Soon will be listed here.

Abstract

An in silico scan of the partially completed genome sequence of Bordetella pertussis and analyses of transcriptional fusions generated with a new integrational vector were used to identify new potential virulence genes. The genes encoding a putative siderophore receptor, adhesins, and an autotransporter protein appeared to be regulated in a manner similar to Bordetella virulence genes by the global virulence regulator BvgAS. In contrast, the gene encoding a putative intimin-like protein appeared to be repressed under conditions of virulence.

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