Neurophysiology of Cancer Pain: From the Laboratory to the Clinic

Overview

Journal Curr Rev Pain

Publisher Current Science

Specialty Neurology

Date 2000 Sep 22

PMID 10998677

Citations 1

Authors

Regan

Peng

Chan

Affiliations

Soon will be listed here.

Abstract

Pain is one of the most distressing symptoms associated with cancer. Basic science research has provided much insight into the mechanisms of peripheral and central pain and the actions of new drugs. Despite these advances, pain accompanying malignancy can be difficult to treat. Pain most commonly presents when the tumor has invaded somatic,visceral, or neural structures. An understanding of pain mechanisms is essential when deciding on the appropriate treatment. New therapeutic options have been developed and will hopefully provide clinicians with tools to successfully alleviate cancer pain.

Citing Articles

Pain in long-term adult survivors of childhood cancers and their siblings: a report from the Childhood Cancer Survivor Study.

Lu Q, Krull K, Leisenring W, Owen J, Kawashima T, Tsao J Pain. 2011; 152(11):2616-2624.

PMID: 21907493 PMC: 3304496. DOI: 10.1016/j.pain.2011.08.006.

References

Howe J, Wang J, Yaksh T . Selective antagonism of the antinociceptive effect of intrathecally applied alpha adrenergic agonists by intrathecal prazosin and intrathecal yohimbine. J Pharmacol Exp Ther. 1983; 224(3):552-8. View

Sotgiu M, Lacerenza M, Marchettini P . Effect of systemic lidocaine on dorsal horn neuron hyperactivity following chronic peripheral nerve injury in rats. Somatosens Mot Res. 1992; 9(3):227-33. DOI: 10.3109/08990229209144773. View

Handwerker H, Kilo S, Reeh P . Unresponsive afferent nerve fibres in the sural nerve of the rat. J Physiol. 1991; 435:229-42. PMC: 1181459. DOI: 10.1113/jphysiol.1991.sp018507. View

Munglani R, Fleming B, Hunt S . Remembrance of times past: the significance of c-fos in pain. Br J Anaesth. 1996; 76(1):1-4. DOI: 10.1093/bja/76.1.1. View

Brescia F, Adler D, Gray G, Ryan M, Cimino J, Mamtani R . Hospitalized advanced cancer patients: a profile. J Pain Symptom Manage. 1990; 5(4):221-7. DOI: 10.1016/0885-3924(90)90015-c. View

Lindsay R, Harmar A . Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature. 1989; 337(6205):362-4. DOI: 10.1038/337362a0. View

Koeller J . Understanding cancer pain. Am J Hosp Pharm. 1990; 47(8 Suppl):S3-6. View

Saito A, Kimura S, Goto K . Calcitonin gene-related peptide as potential neurotransmitter in guinea pig right atrium. Am J Physiol. 1986; 250(4 Pt 2):H693-8. DOI: 10.1152/ajpheart.1986.250.4.H693. View

WALL P, Devor M . Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats. Pain. 1983; 17(4):321-339. DOI: 10.1016/0304-3959(83)90164-1. View

10.

Lema M, Myers D, Penetrante R . Pleural phenol therapy for the treatment of chronic esophageal cancer pain. Reg Anesth. 1992; 17(3):166-70. View

11.

Chabal C, Jacobson L, Mariano A, Chaney E, Britell C . The use of oral mexiletine for the treatment of pain after peripheral nerve injury. Anesthesiology. 1992; 76(4):513-7. DOI: 10.1097/00000542-199204000-00005. View

12.

Coghill R, Talbot J, Evans A, Meyer E, Gjedde A, Bushnell M . Distributed processing of pain and vibration by the human brain. J Neurosci. 1994; 14(7):4095-108. PMC: 6577049. View

13.

Helme R, Andrews P . The effect of nerve lesions on the inflammatory response to injury. J Neurosci Res. 1985; 13(3):453-9. DOI: 10.1002/jnr.490130311. View

14.

Melmon K, WEBSTER M, GOLDFINGER S, Seegmiller J . The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologies. Arthritis Rheum. 1967; 10(1):13-20. DOI: 10.1002/art.1780100103. View

15.

Schaible H, Schmidt R . Activation of groups III and IV sensory units in medial articular nerve by local mechanical stimulation of knee joint. J Neurophysiol. 1983; 49(1):35-44. DOI: 10.1152/jn.1983.49.1.35. View

16.

Eisenach J, Gebhart G . Intrathecal amitriptyline acts as an N-methyl-D-aspartate receptor antagonist in the presence of inflammatory hyperalgesia in rats. Anesthesiology. 1995; 83(5):1046-54. DOI: 10.1097/00000542-199511000-00018. View

17.

Coderre T, Grimes R, Melzack R . Deafferentation and chronic pain in animals: an evaluation of evidence suggesting autotomy is related to pain. Pain. 1986; 26(1):61-84. DOI: 10.1016/0304-3959(86)90174-0. View

18.

Raja S, Meyer R, Campbell J . Peripheral mechanisms of somatic pain. Anesthesiology. 1988; 68(4):571-90. DOI: 10.1097/00000542-198804000-00016. View

19.

Jensen T . Opioids in the brain: supraspinal mechanisms in pain control. Acta Anaesthesiol Scand. 1997; 41(1 Pt 2):123-32. DOI: 10.1111/j.1399-6576.1997.tb04626.x. View

20.

Coderre T, Katz J, Vaccarino A, Melzack R . Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain. 1993; 52(3):259-285. DOI: 10.1016/0304-3959(93)90161-H. View