Bacteremic Pneumonia Due to Multidrug-resistant Pneumococci in 3 Patients Treated Unsuccessfully with Azithromycin and Successfully with Levofloxacin

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2000 Sep 15

PMID 10987733

Citations 26

Authors

C Fogarty

R Goldschmidt

K Bush

Affiliations

Soon will be listed here.

Abstract

Three patients with bacteremic pneumonia caused by multidrug-resistant Streptococcus pneumoniae were treated unsuccessfully with azithromycin. One S. pneumoniae isolate carried a mef determinant for an efflux pump; a second isolate had an erm determinant. All 3 patients were successfully treated with levofloxacin, an antipneumococcal fluoroquinolone.

Citing Articles

Clarithromycin Inhibits Pneumolysin Production via Downregulation of Gene Transcription despite Autolysis Activation.

Domon H, Isono T, Hiyoshi T, Tamura H, Sasagawa K, Maekawa T Microbiol Spectr. 2021; 9(2):e0031821.

PMID: 34468195 PMC: 8557819. DOI: 10.1128/Spectrum.00318-21.

Mechanism of Macrolide-Induced Inhibition of Pneumolysin Release Involves Impairment of Autolysin Release in Macrolide-Resistant Streptococcus pneumoniae.

Domon H, Maekawa T, Yonezawa D, Nagai K, Oda M, Yanagihara K Antimicrob Agents Chemother. 2018; 62(11).

PMID: 30181369 PMC: 6201085. DOI: 10.1128/AAC.00161-18.

Azithromycin use in paediatrics: A practical overview.

Ovetchkine P, Rieder M Paediatr Child Health. 2014; 18(6):311-6.

PMID: 24421702 PMC: 3680256.

Bacteremic pneumonia caused by extensively drug-resistant Streptococcus pneumoniae.

Kang C, Baek J, Jeon K, Kim S, Chung D, Peck K J Clin Microbiol. 2012; 50(12):4175-7.

PMID: 23052301 PMC: 3502956. DOI: 10.1128/JCM.01642-12.

Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae.

Zahner D, Zhou X, Chancey S, Pohl J, Shafer W, Stephens D Antimicrob Agents Chemother. 2010; 54(8):3516-9.

PMID: 20498319 PMC: 2916318. DOI: 10.1128/AAC.01756-09.