[Phalloidin Antagonists. 2. Protective Effect of Disilybine in Phalloidin Poisoning of Isolated Hepatocytes]

Overview

Journal Arzneimittelforschung

Specialty Pharmacology

Date 1975 Apr 1

PMID 1098677

Citations 12

Authors

V E Petzinger

J Homann

M Frimmer

Affiliations

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Abstract

Phalloidin produces marked protrusions on the surface of isolated hepatocytes prepared from rat livers. This typical in-vitro effect of the mushroom toxin is prevented or inhibited by preincubation with disilybin. The antagonistic effect depends on the concentration of disilybin and might be caused by an inhibition of phalloidin binding.

Citing Articles

[Isolated liver cells of the rat under the influence of a toxic factor from burnt human and animal skin (author's transl)].

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Is ligandin relevant for the uptake and storage of phallotoxins in liver cells?.

Ziegler K, Grundmann E, Veil L, Frimmer M Naunyn Schmiedebergs Arch Pharmacol. 1981; 317(4):364-7.

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Affinity labels for membrane components involved in the uptake of bile acids and of phallotoxins by hepatocytes. Development of covalently binding derivatives of bile acids and of compounds related to cholecystographic agents.

Ziegler K, Frimmer M, Moller W, FASOLD H Naunyn Schmiedebergs Arch Pharmacol. 1982; 319(3):249-53.

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A possible reason for the phalloidin tolerance of hepatoma cells.

Grundmann E, Petzinger E, Frimmer M, Boschek C Naunyn Schmiedebergs Arch Pharmacol. 1978; 305(3):253-9.

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Anti-phalloidine and anti-alpha-amanitine action of silybin in comparison with compounds similar to structural parts of silybin.

Trost W, Halbach G Experientia. 1978; 34(8):1051-2.

PMID: 700023 DOI: 10.1007/BF01915341.