Familial Opsonization Defect Associated with Fatal Infantile Dermatitis, Infections, and Histiocytosis

Overview

Journal Arch Dis Child

Specialty Pediatrics

Date 1975 Apr 1

PMID 1096830

Citations 8

Authors

H Scott

E J Moynahan

R A Risdon

B A Harvey

J F Soothill

Affiliations

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Abstract

Members of four generations of a family had a defect of serum opsonization for yeast phagocytosis consistent with dominant inheritance. 2 were healthy, one had chronic osteomyelitis, and the fourth developed a fatal illness in infancy characterized by exfoliative dermatitis, diarrhoea, multiple bacterial infections, and failure to thrive, which resembled the two prevously reported cases with this opsonization defect. At necropsy the infant also had lymphoid depletion, which was possibly secondary, and massive histiocytic infiltration.

Citing Articles

Yeast opsonization in newborn infants and its relationship to parental atopy.

Richardson V, Larcher V, Price J Clin Exp Immunol. 1982; 48(2):411-6.

PMID: 7049453 PMC: 1536474.

Polymorphonuclear neutrophil iodination response as an estimate of defective yeast opsonization.

Roberton D, Dhanjal N, Levinsky R, Mowbray J, Turner M Clin Exp Immunol. 1981; 43(1):208-14.

PMID: 7018758 PMC: 1537125.

Familial hemophagocytic lymphohistiocytosis.

Janka G Eur J Pediatr. 1983; 140(3):221-30.

PMID: 6354720 DOI: 10.1007/BF00443367.

Immunological studies on histiocytosis X. I. Special reference to the chemotactic defect and the HLA antigen.

Tomooka Y, Torisu M, Miyazaki S, Goya N J Clin Immunol. 1986; 6(5):355-62.

PMID: 3490486 DOI: 10.1007/BF00915374.

Letter: Opsonic defects.

Miller M Arch Dis Child. 1975; 50(11):908-9.

PMID: 1211970 PMC: 1545711. DOI: 10.1136/adc.50.11.908-a.

References

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