Regioselective Synthesis of 1,3,5-triaryl-4-alkylpyrazoles: Novel Ligands for the Estrogen Receptor

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2000 Aug 31

PMID 10964377

Citations 13

Authors

Y R Huang

J A Katzenellenbogen

Affiliations

Soon will be listed here.

Abstract

[reaction: see structure] A regioselective synthesis of 4-alkyl-1,3,5-triarylpyrazoles has been developed for the preparation of unsymmetrically substituted systems of interest as ligands for the estrogen receptor.

Citing Articles

Acrylic boronate: a multifunctional C3 building block for catalytic synthesis of rare organoborons and chemoselective heterobifunctional ligations.

Lin S, Wang L, Sharma A Chem Sci. 2021; 12(22):7924-7929.

PMID: 34168846 PMC: 8188605. DOI: 10.1039/d1sc00905b.

Styrylpyrazoles: Properties, Synthesis and Transformations.

Gomes P, Ouro P, Silva A, Silva V Molecules. 2020; 25(24).

PMID: 33322752 PMC: 7764498. DOI: 10.3390/molecules25245886.

Thermal electron-transfer-induced oxidation of 2-pyrazolines.

Memarian H, Minakar R Mol Divers. 2019; 23(4):953-964.

PMID: 30712117 DOI: 10.1007/s11030-019-09922-x.

A novel pseudo six-component synthesis of functionalized pyrazoles in ethanol by cascade reaction.

Rezvanian A, Babashah M, Anafcheh M Mol Divers. 2019; 23(4):875-883.

PMID: 30635761 DOI: 10.1007/s11030-018-9908-2.

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins.

Ippagunta S, Pollock J, Sharma N, Lin W, Chen T, Tawaratsumida K Sci Signal. 2018; 11(543).

PMID: 30108181 PMC: 7195875. DOI: 10.1126/scisignal.aaq1077.