Act1, an NF-kappa B-activating Protein

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2000 Aug 30

PMID 10962024

Citations 91

Authors

X Li

M Commane

H Nie

X Hua

M Chatterjee-Kishore

D Wald

M Haag

G R Stark

Affiliations

Soon will be listed here.

Abstract

Use of an NF-kappaB-dependent selectable marker facilitated the isolation of a cell line containing a cDNA encoding Act1, an NF-kappaB activator. Act1 associates with and activates IkappaB kinase (IKK), leading to the liberation of NF-kappaB from its complex with IkappaB. Many signaling pathways that liberate NF-kappaB also activate activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). Act1 also activates JNK, suggesting that it might be part of a multifunctional complex involved in the activation of both NF-kappaB and JNK. Act1 fails to activate NF-kappaB in an IL-1-unresponsive mutant cell line in which all known signaling components are present, suggesting that it interacts with an unknown component in IL-1 signaling.

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