Construction and Biological Characterization of an Infectious Molecular Clone of HIV Type 1GB8

Overview

Journal AIDS Res Hum Retroviruses

Publisher Mary Ann Liebert

Specialty Infectious Diseases

Date 2000 Aug 24

PMID 10954893

Citations 2

Authors

P NOVELLI

C Vella

J Oxford

R S Daniels

Affiliations

Soon will be listed here.

Abstract

Here we report the construction, sequencing, and repair of a molecular clone of HIV-1GB8, a virus representative of HIV-1 subtype B strains circulating in the UK. The phenotype of virus produced by the clone matches that of the parental virus. The molecular clone will be used in the production of attenuated virus stocks for chemical inactivation to allow development of faccines based on killed whole virus preparations.

Citing Articles

Validation of Variant Assembly Using HAPHPIPE with Next-Generation Sequence Data from Viruses.

Gibson K, Steiner M, Rentia U, Bendall M, Perez-Losada M, Crandall K Viruses. 2020; 12(7).

PMID: 32674515 PMC: 7412389. DOI: 10.3390/v12070758.

Infectious molecular clone of a recently transmitted pediatric human immunodeficiency virus clade C isolate from Africa: evidence of intraclade recombination.

Grisson R, Chenine A, Yeh L, He J, Wood C, Bhat G J Virol. 2004; 78(24):14066-9.

PMID: 15564517 PMC: 533957. DOI: 10.1128/JVI.78.24.14066-14069.2004.