» Articles » PMID: 10944795

Introduction to Immunostimulatory DNA Sequences

Overview
Date 2000 Aug 17
PMID 10944795
Citations 4
Authors
Affiliations
Soon will be listed here.
Citing Articles

DyNAVacS: an integrative tool for optimized DNA vaccine design.

Harish N, Gupta R, Agarwal P, Scaria V, Pillai B Nucleic Acids Res. 2006; 34(Web Server issue):W264-6.

PMID: 16845007 PMC: 1538838. DOI: 10.1093/nar/gkl242.


A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif.

Kandimalla E, Bhagat L, Zhu F, Yu D, Cong Y, Wang D Proc Natl Acad Sci U S A. 2003; 100(24):14303-8.

PMID: 14610275 PMC: 283587. DOI: 10.1073/pnas.2335947100.


Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles.

Kandimalla E, Bhagat L, Wang D, Yu D, Zhu F, Tang J Nucleic Acids Res. 2003; 31(9):2393-400.

PMID: 12711684 PMC: 154229. DOI: 10.1093/nar/gkg343.


Activation of the immune system by bacterial CpG-DNA.

Hacker G, Redecke V, Hacker H Immunology. 2002; 105(3):245-51.

PMID: 11918685 PMC: 1782662. DOI: 10.1046/j.0019-2805.2001.01350.x.

References
1.
Sonehara K, Saito H, Kuramoto E, Yamamoto S, Yamamoto T, Tokunaga T . Hexamer palindromic oligonucleotides with 5'-CG-3' motif(s) induce production of interferon. J Interferon Cytokine Res. 1996; 16(10):799-803. DOI: 10.1089/jir.1996.16.799. View

2.
Bestor T . The host defence function of genomic methylation patterns. Novartis Found Symp. 1998; 214:187-95; discussion 195-9, 228-32. DOI: 10.1002/9780470515501.ch11. View

3.
Bird A . DNA methylation and the frequency of CpG in animal DNA. Nucleic Acids Res. 1980; 8(7):1499-504. PMC: 324012. DOI: 10.1093/nar/8.7.1499. View

4.
Kobayashi H, Van Uden J, Nguyen M, Kornbluth R, Raz E . Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences. Int Immunol. 1999; 11(7):1111-8. DOI: 10.1093/intimm/11.7.1111. View

5.
Hacker H, Mischak H, Miethke T, Liptay S, Schmid R, Sparwasser T . CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J. 1998; 17(21):6230-40. PMC: 1170949. DOI: 10.1093/emboj/17.21.6230. View