T Cell-dependent Mediator in the Immune Response. III. The Role of Non-specific Factor (NSF) in the in Vitro Immune Response

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1975 Mar 1

PMID 1092612

Citations 17

Authors

H Waldmann

Affiliations

Soon will be listed here.

Abstract

Evidence is presented which suggests that T cell-dependent nonspecific factor (NSF) cannot be the sole mediator of 'co-operation' for all types of thymus-dependent antibody response. NSF can replace the requirement for T cells in responses to hapten conjugated to particulate carriers, but cannot do so in responses to hapten conjugates of soluble thymus-dependent carriers.

Citing Articles

Analysis of the response of B cells from CBA/N-defective mice to nonspecific T cell help.

Greenstein J, Lord E, Kappler J, Marrack P J Exp Med. 1981; 154(5):1608-17.

PMID: 6975350 PMC: 2186522. DOI: 10.1084/jem.154.5.1608.

Antigen-specific T-helper cells stimulate H-2-compatible and H-2-incompatible B-cell blasts polyclonally.

SCHREIER M, Andersson J, Lernhardt W, Melchers F J Exp Med. 1980; 151(1):194-203.

PMID: 6965306 PMC: 2185768. DOI: 10.1084/jem.151.1.194.

T cell help mechanisms in the in vitro antibody response: the role of linked and non-linked recognition interactions.

SULLIVAN C, Waldmann H Immunology. 1984; 51(2):343-50.

PMID: 6607212 PMC: 1454428.

Multiple thymus-derived helper cell activities involved in antibody responses.

Endres R, Marrack P Surv Immunol Res. 1982; 1(2):117-21.

PMID: 6195711 DOI: 10.1007/BF02918334.

The role of H-2-linked genes in helper T cell function. VII. Expression of I region and immune response genes by B cells in bystander help assays.

Marrack P, Kappler J J Exp Med. 1980; 152(5):1274-88.

PMID: 6159447 PMC: 2185988. DOI: 10.1084/jem.152.5.1274.

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