Time Course of Inwardly Rectifying K(+) Current Reduction in Glial Cells Surrounding Ischemic Brain Lesions

Overview

Journal Brain Res

Specialty Neurology

Date 2000 Aug 5

PMID 10924692

Citations 9

Authors

H Koller

M Schroeter

S Jander

G Stoll

M Siebler

Affiliations

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Abstract

K(+) currents of activated glial cells surrounding ischemic infarcts are investigated using acutely dissociated cells from the periinfarct area after permanent middle cerebral artery occlusion in rats. Inwardly rectifying K(+) currents (K(IR)) were markedly reduced in cells neighboring infarcts with maximal alteration at day 3 after infarct followed by a partial recovery. This reduction of glial K(IR) currents may contribute to the functional disturbances in the periinfarct area.

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