Aldose Reductase-deficient Mice Develop Nephrogenic Diabetes Insipidus

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 2000 Jul 27

PMID 10913167

Citations 50

Authors

H T Ho

S K Chung

J W LAW

B C Ko

S C Tam

H L Brooks

M A Knepper

S S Chung

Affiliations

Soon will be listed here.

Abstract

Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.

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