Peripheral Opioid Modulation of Visceral Pain
Overview
Authors
Affiliations
Opioids are widely and successfully used for control of pain, including pain arising from the viscera. Constipating, sedating, respiratory depressant and other effects of opioids, however, often limit their long-term use in the treatment of a variety of visceral pain states. Accordingly, understanding visceral pain mechanisms and its modulation is important to developing improved strategies for pain control.
Ten Barge J, van den Bosch G, Slater R, van den Hoogen N, Reiss I, Simons S Paediatr Drugs. 2025; 27(2):201-220.
PMID: 39752054 PMC: 11829917. DOI: 10.1007/s40272-024-00676-0.
Jalava N, Kaskinoro J, Chapman H, Morales M, Metsankyla H, Heinonen S Int J Mol Sci. 2023; 24(4).
PMID: 36834762 PMC: 9964505. DOI: 10.3390/ijms24043350.
Staal R, Gandhi A, Zhou H, Cajina M, Jacobsen A, Hestehave S Purinergic Signal. 2022; 18(4):499-514.
PMID: 36001278 PMC: 9832206. DOI: 10.1007/s11302-022-09892-0.
Terashvili M, Talluri B, Palangmonthip W, Iczkowski K, Sanvanson P, Medda B Neuropharmacology. 2021; 196:108701.
PMID: 34256047 PMC: 8435000. DOI: 10.1016/j.neuropharm.2021.108701.
Advances in Achieving Opioid Analgesia Without Side Effects.
Machelska H, Celik M Front Pharmacol. 2018; 9:1388.
PMID: 30555325 PMC: 6282113. DOI: 10.3389/fphar.2018.01388.