Nonimmune Interaction of the SfbI Protein of Streptococcus Pyogenes with the Immunoglobulin G F(ab')(2) Fragment

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 2000 Jul 19

PMID 10899889

Citations 3

Authors

E Medina

K Schulze

G S Chhatwal

C A Guzman

Affiliations

Soon will be listed here.

Abstract

Fibronectin-binding protein I (SfbI) of Streptococcus pyogenes binds to mouse immunoglobulin G (IgG) but not to IgA or IgM in a nonimmune fashion. The fibronectin-binding domains of SfbI were responsible for this activity, which was targeted to the IgG F(ab')(2) fragment. SfbI also binds to B cells but not to CD4(+) or CD8(+) lymphocytes.

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