Regulators of Vascular Permeability: Potential Sites for Intervention in the Treatment of Macular Edema
Overview
Authors
Affiliations
Rather than being a non-specific reaction to a noxious stimulus, breakdown of the capillary blood-retinal barrier causing macular edema appears to be dependent on a number of active processes which may be open to pharmacological manipulation. Extracellular influences which may affect barrier function include serum and neighboring cell types, which act though cytokines, such as vascular endothelial growth factor and transforming growth factor-beta, and other factors. A number of intracellular pathways acting on the cytoskeleton and components of the intercellular junctional complexes have been identified which mediate agonist-induced leak of the vascular endothelium. The further elucidation of these processes may be useful in the development of better treatments for breakdown of the inner blood-retinal barrier.
Radiation Retinopathy: Detection and Management Strategies.
Sahoo N, Ranjan R, Tyagi M, Agrawal H, Reddy S Clin Ophthalmol. 2021; 15:3797-3809.
PMID: 34526764 PMC: 8436254. DOI: 10.2147/OPTH.S219268.
Kaplan R, Chaugule S, Finger P Br J Ophthalmol. 2017; 101(12):1694-1698.
PMID: 28416492 PMC: 5754875. DOI: 10.1136/bjophthalmol-2017-310315.
Therapeutic potential of a monoclonal antibody blocking the Wnt pathway in diabetic retinopathy.
Lee K, Hu Y, Ding L, Chen Y, Takahashi Y, Mott R Diabetes. 2012; 61(11):2948-57.
PMID: 22891217 PMC: 3478529. DOI: 10.2337/db11-0300.
Ablonczy Z, Prakasam A, Fant J, Fauq A, Crosson C, Sambamurti K J Biol Chem. 2009; 284(44):30177-86.
PMID: 19723623 PMC: 2781573. DOI: 10.1074/jbc.M109.032391.
[Cystoid macular edema in uveitis].
Thurau S Ophthalmologe. 2005; 102(5):485-90.
PMID: 15747121 DOI: 10.1007/s00347-005-1183-9.