Sequence and Transfection of BoLA-DRB3 CDNAs

Overview

Journal Anim Genet

Specialties Biology
Genetics

Date 2000 Jul 15

PMID 10895315

Citations 3

Authors

G C Russell

D C Fraser

S Craigmile

R A Oliver

B M Dutia

E J Glass

Affiliations

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Abstract

Bovine MHC (BoLA-) DRB3 alleles encoded by the DH8A, DH22A and DH24A class II haplotypes were cloned from cDNA and characterized by sequence analysis. Comparison with other full-length DRB3 sequences suggested that DRB3 alleles may have evolved through multiple lineages. All three BoLA-DRB3 alleles were shown to express on the surface of transfected cells, and the transfectants were used to define or confirm the class II specificity of a panel of monoclonal antibodies.

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