The Serotonergic Agent M-chlorophenylpiperazine Induces Migraine Attacks: A Controlled Study
Affiliations
In a double-blind study versus placebo, the serotonergic agent m-chlorophenylpiperazine (mCPP) was administered to 20 healthy control subjects and 19 migraineurs to investigate the ability of mCPP (0.5 mg/kg) to induce typical migraine attacks. In the following 24 hours there were more migraines after mCPP than after placebo in both groups. These findings are consistent with involvement of 5HT2B,2C,1A receptor subtypes in the pathophysiology of migraine.
Cortical pain processing in migraine.
Coppola G, Parisi V, Di Renzo A, Pierelli F J Neural Transm (Vienna). 2019; 127(4):551-566.
PMID: 31598777 DOI: 10.1007/s00702-019-02089-7.
Deen M, Hougaard A, Hansen H, Schain M, Dyssegaard A, Knudsen G JAMA Neurol. 2019; 76(7):834-840.
PMID: 31135819 PMC: 6547094. DOI: 10.1001/jamaneurol.2019.0755.
High brain serotonin levels in migraine between attacks: A 5-HT receptor binding PET study.
Deen M, Hansen H, Hougaard A, Norgaard M, Eiberg H, Lehel S Neuroimage Clin. 2018; 18:97-102.
PMID: 29387527 PMC: 5790018. DOI: 10.1016/j.nicl.2018.01.016.
Pineyro M, Sosa G, Finozzi M, Stecker N, Pisabarro R, Belzarena M Clin Case Rep. 2017; 5(11):1868-1873.
PMID: 29152289 PMC: 5676261. DOI: 10.1002/ccr3.1208.
Chehel Cheraghi S, Ebrahimi Daryani N, Ghabaee M Middle East J Dig Dis. 2016; 8(4):282-288.
PMID: 27957291 PMC: 5145295. DOI: 10.15171/mejdd.2016.37.