NMDA Receptor Activation: Critical Role in Oxidant Tissue Injury

Overview

Journal Free Radic Biol Med

Specialties Biochemistry
Biology
General Medicine

Date 2000 Jul 13

PMID 10889461

Citations 12

Authors

S I Said

H Pakbaz

H I Berisha

S Raza

Affiliations

Soon will be listed here.

Abstract

The excitatory amino acid glutamate serves important neurologic functions, but overactivation of its N-methyl-D-aspartate (NMDA) receptor is toxic to neurons (excitotoxicity). We report that NMDA receptor blocker MK-801 (dizocilpine maleate) attenuated oxidant injury induced by paraquat or by xanthine oxidase. We conclude that excitotoxicity may be a key factor in oxidant tissue injury.

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