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Notch Signal Transduction: a Real Rip and More

Overview
Publisher Elsevier
Specialties Biology
Genetics
Date 2000 Jul 13
PMID 10889061
Citations 68
Authors
Affiliations
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Abstract

The Notch signaling pathway functions in a wide variety of processes that regulate tissue patterning and morphogenesis in developing vertebrates and invertebrates. Research on the mechanism of ligand-induced Notch signal transduction has revealed a novel and essential element in the signal cascade. Some recent findings support a model in which sequential proteolytic cleavage serves to regulate Notch signal transduction.

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