Serum KL-6 in Adult Patients with Polymyositis and Dermatomyositis

Overview

Journal Rheumatology (Oxford)

Publisher Oxford University Press

Specialty Rheumatology

Date 2000 Jul 11

PMID 10888708

Citations 23

Authors

M Kubo

H Ihn

K Yamane

K Kikuchi

N Yazawa

Y Soma

K Tamaki

Affiliations

Soon will be listed here.

Abstract

Objective: To determine the serum levels of KL-6, a mucin-like high-molecular-weight glycoprotein, in polymyositis/dermatomyositis (PM/DM) patients.

Methods: Serum samples from 42 adult PM/DM patients and 38 healthy control subjects were examined using specific enzyme-linked immunosorbent assay (ELISA) systems.

Results: The serum levels of KL-6 in the PM/DM patients were significantly higher than those of the healthy controls. The elevated serum KL-6 levels correlated with the presence of interstitial lung disease (ILD) and decreased percentage diffusing capacity of carbon monoxide (%DLco) in the PM/DM patients. The serum KL-6 levels inversely correlated with %DLco and percentage vital capacity. Additionally, the serum KL-6 levels were elevated in five of the seven DM patients with malignant neoplasia.

Conclusions: These results suggest that the serum KL-6 level might be a useful serum marker for ILD and internal malignancy in PM/DM.

Citing Articles

Clinically Relevant Biomarkers in Connective Tissue Disease-Associated Interstitial Lung Disease.

Pugashetti J, Khanna D, Kazerooni E, Oldham J Immunol Allergy Clin North Am. 2023; 43(2):411-433.

PMID: 37055096 PMC: 10584384. DOI: 10.1016/j.iac.2023.01.012.

KL-6 as a Biomarker of Interstitial Lung Disease Development in Patients with Sjögren Syndrome: A Retrospective Case-Control Study.

Chiu Y, Chu C, Lu C, Liu F, Tang S, Chu S J Inflamm Res. 2022; 15:2255-2262.

PMID: 35422651 PMC: 9005069. DOI: 10.2147/JIR.S352085.

Clinical Characteristics of Anti-TIF-1γ Antibody-Positive Dermatomyositis Associated with Malignancy.

Harada Y, Tominaga M, Iitoh E, Kaieda S, Koga T, Fujimoto K J Clin Med. 2022; 11(7).

PMID: 35407533 PMC: 8999723. DOI: 10.3390/jcm11071925.

Bronchoalveolar lavage and lung biopsy in connective tissue diseases, to do or not to do?.

Tomassetti S, Colby T, Wells A, Poletti V, Costabel U, Matucci-Cerinic M Ther Adv Musculoskelet Dis. 2021; 13:1759720X211059605.

PMID: 34900002 PMC: 8664307. DOI: 10.1177/1759720X211059605.

Role of MUC1 rs4072037 polymorphism and serum KL-6 levels in patients with antisynthetase syndrome.

Remuzgo-Martinez S, Atienza-Mateo B, Ocejo-Vinyals J, Genre F, Pulito-Cueto V, Mora-Cuesta V Sci Rep. 2021; 11(1):22574.

PMID: 34799647 PMC: 8604941. DOI: 10.1038/s41598-021-01992-y.