Apoptosis Induced by the Flavonoid from Lemon Fruit (Citrus Limon BURM. F.) and Its Metabolites in HL-60 Cells

Overview

Journal Biosci Biotechnol Biochem

Publisher Oxford University Press

Specialties Biochemistry
Biotechnology

Date 2000 Jul 6

PMID 10879486

Citations 7

Authors

S Ogata

Y Miyake

K Yamamoto

K Okumura

H Taguchi

Affiliations

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Abstract

The flavonoid from lemon fruit (Citrus limon BURM. f.) and its metabolites, particularly eriodictyol, 3,4-dihydroxyhydrocinnamic acid, and phloroglucinol had the function of DNA fragmentation in HL-60 cells when analyzed by flow cytometry. An apoptotic DNA ladder and chromatin condensation were observed in HL-60 cells when treated with these compounds. The caspase inhibitor prevented DNA fragmentation. These compounds are anticipated to be useful for medical purposes.

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