Biclonal Chronic Lymphocytic Leukemia

Overview

Journal Am J Clin Pathol

Publisher Oxford University Press

Specialty Pathology

Date 2000 Jun 30

PMID 10874880

Citations 8

Authors

E D Hsi

G Hoeltge

R R Tubbs

Affiliations

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Abstract

Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. We report 2 cases of biclonal CLL. Two elderly men were encountered with an absolute lymphocytosis consisting of the typical CD5+, CD19+, CD23+ B-cell population seen in CLL; however, immunoglobulin light chain restriction by flow cytometry was not apparent as B cells expressed kappa or lambda light chains without a clear monotypic population. Molecular genetic analysis of flow cytometry-sorted cells (kappa and lambda populations) revealed in both cases 2 monoclonal B-cell populations. The characterization of these cases and a review of the issues surrounding biclonal CLL are presented.

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