Gamma and Beta Frequency Oscillations in Response to Novel Auditory Stimuli: A Comparison of Human Electroencephalogram (EEG) Data with in Vitro Models

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2000 Jun 15

PMID 10852953

Citations 114

Authors

C Haenschel

T Baldeweg

R J Croft

M Whittington

J Gruzelier

Affiliations

Soon will be listed here.

Abstract

Investigations using hippocampal slices maintained in vitro have demonstrated that bursts of oscillatory field potentials in the gamma frequency range (30-80 Hz) are followed by a slower oscillation in the beta 1 range (12-20 Hz). In this study, we demonstrate that a comparable gamma-to-beta transition is seen in the human electroencephalogram (EEG) in response to novel auditory stimuli. Correlations between gamma and beta 1 activity revealed a high degree of interdependence of synchronized oscillations in these bands in the human EEG. Evoked (stimulus-locked) gamma oscillations preceded beta 1 oscillations in response to novel stimuli, suggesting that this may be analogous to the gamma-to-beta shift observed in vitro. Beta 1 oscillations were the earliest discriminatory responses to show enhancement to novel stimuli, preceding changes in the broad-band event-related potential (mismatch negativity). Later peaks of induced beta activity over the parietal cortex were always accompanied by an underlying gamma frequency oscillation as seen in vitro. A further analogy between in vitro and human recordings was that both gamma and beta oscillations habituated markedly after the initial novel stimulus presentation.

Citing Articles

A parametric investigation of binaural beats for brain entrainment and enhancing sustained attention.

Melnichuk A, Cooper Jr R, Hawk Jr L Sci Rep. 2025; 15(1):4308.

PMID: 39910150 PMC: 11799511. DOI: 10.1038/s41598-025-88517-z.

Robust skin-integrated conductive biogel for high-fidelity detection under mechanical stress.

Li T, Qi H, Zhao C, Li Z, Zhou W, Li G Nat Commun. 2025; 16(1):88.

PMID: 39747025 PMC: 11695986. DOI: 10.1038/s41467-024-55417-1.

Differential effects of mindfulness treatment and mobile neurofeedback on event-related potentials in early posterior negativity in cancer patients: a clinical-experimental parallel group design.

Fink M, Schmidt K, Kowalski A, Pasche S, Albrot C, Krawutschke M Front Psychol. 2024; 15:1395032.

PMID: 39411559 PMC: 11473409. DOI: 10.3389/fpsyg.2024.1395032.

The neuromechanical of Beta-band corticomuscular coupling within the human motor system.

Peng J, Zikereya T, Shao Z, Shi K Front Neurosci. 2024; 18:1441002.

PMID: 39211436 PMC: 11358111. DOI: 10.3389/fnins.2024.1441002.

Delta waves as a sign of cortical plasticity after full-face transplantation.

Suzen E, Savkliyildiz A, Ozkan O, Colak O, Apaydin Dogan E, Ozkan O Sci Rep. 2024; 14(1):16454.

PMID: 39014053 PMC: 11252439. DOI: 10.1038/s41598-024-67469-w.

References

Basar E, Rosen B, Basar-Eroglu C, Greitschus F . The associations between 40 Hz-EEG and the middle latency response of the auditory evoked potential. Int J Neurosci. 1987; 33(1-2):103-17. DOI: 10.3109/00207458708985933. View

Lehmann D, Skrandies W . Reference-free identification of components of checkerboard-evoked multichannel potential fields. Electroencephalogr Clin Neurophysiol. 1980; 48(6):609-21. DOI: 10.1016/0013-4694(80)90419-8. View

Tiitinen H, Sinkkonen J, Reinikainen K, Alho K, Lavikainen J, Naatanen R . Selective attention enhances the auditory 40-Hz transient response in humans. Nature. 1993; 364(6432):59-60. DOI: 10.1038/364059a0. View

von Stein A, Rappelsberger P, Sarnthein J, Petsche H . Synchronization between temporal and parietal cortex during multimodal object processing in man. Cereb Cortex. 1999; 9(2):137-50. DOI: 10.1093/cercor/9.2.137. View

Naatanen R, Winkler I . The concept of auditory stimulus representation in cognitive neuroscience. Psychol Bull. 1999; 125(6):826-59. DOI: 10.1037/0033-2909.125.6.826. View

Whittington M, Traub R, Faulkner H, Stanford I, Jefferys J . Recurrent excitatory postsynaptic potentials induced by synchronized fast cortical oscillations. Proc Natl Acad Sci U S A. 1997; 94(22):12198-203. PMC: 23749. DOI: 10.1073/pnas.94.22.12198. View

Roelfsema P, Engel A, Konig P, Singer W . Visuomotor integration is associated with zero time-lag synchronization among cortical areas. Nature. 1997; 385(6612):157-61. DOI: 10.1038/385157a0. View

MacDonald K, Fifkova E, Jones M, Barth D . Focal stimulation of the thalamic reticular nucleus induces focal gamma waves in cortex. J Neurophysiol. 1998; 79(1):474-7. DOI: 10.1152/jn.1998.79.1.474. View

Miltner W, Braun C, Arnold M, Witte H, Taub E . Coherence of gamma-band EEG activity as a basis for associative learning. Nature. 1999; 397(6718):434-6. DOI: 10.1038/17126. View

10.

Makeig S, Jung T . Tonic, phasic, and transient EEG correlates of auditory awareness in drowsiness. Brain Res Cogn Brain Res. 1996; 4(1):15-25. DOI: 10.1016/0926-6410(95)00042-9. View

11.

Sokolov E . Higher nervous functions; the orienting reflex. Annu Rev Physiol. 1963; 25:545-80. DOI: 10.1146/annurev.ph.25.030163.002553. View

12.

Traub R, Whittington M, Buhl E, Jefferys J, Faulkner H . On the mechanism of the gamma --> beta frequency shift in neuronal oscillations induced in rat hippocampal slices by tetanic stimulation. J Neurosci. 1999; 19(3):1088-105. PMC: 6782135. View

13.

Yamaguchi S, Knight R . Anterior and posterior association cortex contributions to the somatosensory P300. J Neurosci. 1991; 11(7):2039-54. PMC: 6575477. View

14.

Pfurtscheller G . Mapping of event-related desynchronization and type of derivation. Electroencephalogr Clin Neurophysiol. 1988; 70(2):190-3. DOI: 10.1016/0013-4694(88)90119-8. View

15.

Pantev C, Makeig S, Hoke M, GALAMBOS R, Hampson S, Gallen C . Human auditory evoked gamma-band magnetic fields. Proc Natl Acad Sci U S A. 1991; 88(20):8996-9000. PMC: 52638. DOI: 10.1073/pnas.88.20.8996. View

16.

Baldeweg T, Richardson A, Watkins S, Foale C, Gruzelier J . Impaired auditory frequency discrimination in dyslexia detected with mismatch evoked potentials. Ann Neurol. 1999; 45(4):495-503. DOI: 10.1002/1531-8249(199904)45:4<495::aid-ana11>3.0.co;2-m. View

17.

Marshall L, Molle M, Bartsch P . Event-related gamma band activity during passive and active oddball tasks. Neuroreport. 1996; 7(9):1517-20. DOI: 10.1097/00001756-199606170-00016. View

18.

Gruzelier J, Eves F, Connolly J, Hirsch S . Orienting, habituation, sensitisation, and dishabituation in the electrodermal system of consecutive, drug free, admissions for schizophrenia. Biol Psychol. 1981; 12(2-3):187-209. DOI: 10.1016/0301-0511(81)90011-9. View

19.

Knight R, Nakada T . Cortico-limbic circuits and novelty: a review of EEG and blood flow data. Rev Neurosci. 1998; 9(1):57-70. DOI: 10.1515/revneuro.1998.9.1.57. View

20.

Whittington M, Traub R, Jefferys J . Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature. 1995; 373(6515):612-5. DOI: 10.1038/373612a0. View