Preferential Generation of Killer or Helper T-lymphocyte Activity Directed to the Tumour-associated Transplantation Antigens

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1976 Aug 1

PMID 1085283

Citations 6

Authors

H Fujiwara

T Hamaoka

K Teshima

H Aoki

M Kitagawa

Affiliations

Soon will be listed here.

Abstract

Induction of killer and helper T-cell activities towards transplantation antigens of two tumour cell lines was analysed in the allogeneic and syngeneic host combinations. The lymphoid cells from C57BL/6 mice immunized with allogeneic viable or mitomycin C-treated X-5563 plasmacytoma cells derived from C3H/He mice revealed both killer and helper T-cell activities against alloantigens, whereas cells from mice immunized with tumour cells killed by a freezing and thawing procedure revealed predominantly helper T-cell activity. On the other hand, when C3H/He mice were immunized with viable syngeneic X-5563 plasmacytoma or MM102 mammary tumour cells, the former generated preferentially killer T-cell activity, whereas the latter induced predominantly helper T-cell activity against tumour-associated transplantation antigens. Thus, immunization with transplantation antigen(s) does not always induce both helper and killer T-cell activities in parallel, but a certain antigenic system induces predominantly one type of T-cell response, thus indicating that two distinct subsets of helper and killer T cells against the transplantation antigen(s) can be raised independently without an absolute requirement of collaboration between these different T-cells subsets.

Citing Articles

The role of tumor-specific Lyt-1+2- T cells in eradicating tumor cells in vivo. II. Lyt-1+2- T cells have potential to reject antigenically irrelevant (bystander) tumor cells on activation with the specific target tumor cells.

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Effect of recombinant interleukin 2 (R-IL2) on in vivo growth of murine myeloma X5563.

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The mode of recognition of tumor antigens by noncytolytic-type antitumor T cells: role of antigen-presenting cells and their surface class I and class II H-2 molecules.

Sakamoto K, Nakajima H, Shimizu J, Katagiri T, Kiyotaki C, Fujiwara H Cancer Immunol Immunother. 1988; 27(3):261-6.

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Studies on macrophage-activating factor (MAF) in antitumor immune responses. II. Molecular characterization of MAF produced by the tumor-immune Lyt-1+2- T cell subset.

Nakajima H, Izumi Y, Sugihara S, Satoh Y, Isumi S, Gotoh T Cancer Immunol Immunother. 1987; 25(3):201-8.

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Regulatory functions of hapten-reactive helper and suppressor T lymphocytes. III. Amplification of a generation of tumor-specific killer T-lymphocyte activities by suppressor T-cell-depleted hapten-reactive T lymphocytes.

Hamaoka T, Fujiwara H, Teshima K, Aoki H, Yamamoto H, Kitagawa M J Exp Med. 1979; 149(1):185-99.

PMID: 310858 PMC: 2184739. DOI: 10.1084/jem.149.1.185.

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