Increased Levels of Circulating Interleukin-18 in Patients with Advanced Tuberculosis

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 2000 Jun 14

PMID 10852745

Citations 19

Authors

G Yamada

N Shijubo

K Shigehara

H Okamura

M Kurimoto

S Abe

Affiliations

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Abstract

Interleukin-18 (IL-18) has recently been identified as an interferon- gamma-inducing factor and it plays an important role in the Th1 response. We measured serum levels of IL-18 and interferon-gamma (IFN-gamma) in 43 patients with pulmonary tuberculosis and 25 healthy control subjects. Significantly increased levels of circulating IL-18 and IFN-gamma were found in pulmonary tuberculosis as compared with those in healthy control subjects. Circulating IL-18 and IFN-gamma correlated with the extent of disease in pulmonary tuberculosis. We found significantly increased levels of circulating IL-18 and IFN-gamma in the patients with high-grade fever. Circulating IL-18 significantly correlated with circulating IFN-gamma. IL-18 may play an important role in immune response to human infection with Mycobacterium tuberculosis.

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